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| - | [[image:2byn.png |left|300px]]
| + | #REDIRECT [[Acetylcholine binding protein]] |
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| - | Acetylcholine binding protein (AChBP) is secreted by snails into cholinergic synapses, where it modulates transmission by binding acetylcholine (ACh). Sequence alignment revealed high similarity to the extracellular domains of the ligand-binding subunits of the nicotinic acetylcholine receptor (nAChR). The crystal structure of the AChBP homopentamer indeed provides a valuable model for identifying the nature of the ligand-binding domains and of the subunit interfaces of the nAChR. Furthermore, crystal structures of complexes of AChBP with various agonists and antagonists have provided detailed insight into the neurotransmitter binding site of nAChRs. | + | |
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| - | = AChBP - Apo proteins =
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| - | [[2w8e]], [[2byn]] – '''''Aplysia californica''''' (AcAChBP) <br />
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| - | [[1ux2]], [[1i9b]] – '''''Lymnaea stagnalis''''' (LsAChBP) <br />
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| - | [[2bj0]] – '''''Bulinus truncatus'''''
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| - | = AChBP + marine biotoxins =
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| - | [[2wzy]] – AcAChBP + 13-desmethyl spirolide C <br />
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| - | [[2x00]] - AcAChBP + gymnodimine A <br />
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| - | = AChBP + partial agonists; Activate the receptor with partial efficacy =
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| - | [[2wn9]] - AcAChBP + 4-OH-DMXBA <br />
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| - | [[2wnc]] - AcAChBP + tropisetron <br />
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| - | [[2wnj]] - AcAChBP + DMXBA <br />
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| - | [[2wnl]] – AcAChBP + anabaseine [ <br />
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| - | = AChBP+ions; Mimicking the ion conductance of the receptor =
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| - | [[3gua]] – AcAChBP + sulfate <br />
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| - | = AChBP+ neonicotinoids; Insecticides with lower affinity to mammals =
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| - | [[3c79]] - AcAChBP + imidacloprid <br />
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| - | [[2zju]] – LsAChBP + imidacloprid <br />
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| - | [[3c84]] – AcAChBP + thiacloprid <br />
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| - | [[2zjv]] – LsAChBP+clothianidin <br />
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| - | = AChBP+ non-competitive inhibitors which bind at site different than the active site and reduce the rate of receptor reaction =
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| - | [[2pjz]] - AcAChBP+cocaine <br />
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| - | [[2ph9]] - AcAChBP+galanthamine <br />
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| - | [[2w8f]], [[2w8g]] – AcAChBP + in silico compounds <br />
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| - | = AChBP+ peptide inhibitors =
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| - | [[2c9t]], [[2byp]], [[2br8]] - AcAChBP+conotoxin IMI <br />
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| - | [[1yi5]] – AcAChBP+cobratoxin <br />
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| - | = AChBP+ nicotinic agonists enhance the action of the nAChR =
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| - | [[2pgz]] – AcAChBP+cocaine <br />
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| - | [[2byr]] - AcAChBP+methyllycaconitine <br />
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| - | [[2bys]] - AcAChBP+lobeline <br />
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| - | = AChBP+ ligand homologs of the ligand acetylcholine =
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| - | [[1uv6]] - LsAChBP+ carbamylcholine <br />
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| - | [[1uw6]] - LsAChBP+nicotine <br />
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| - | = AChBP+others =
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| - | [[2br7]] – AcAChBP+ HEPES
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