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1qjj
From Proteopedia
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| - | [[Image:1qjj.jpg|left|200px]]<br /><applet load="1qjj" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1qjj, resolution 1.86Å" /> | ||
| - | '''STRUCTURE OF ASTACIN WITH A HYDROXAMIC ACID INHIBITOR'''<br /> | ||
| - | == | + | ==Structure of astacin with a hydroxamic acid inhibitor== |
| - | + | <StructureSection load='1qjj' size='340' side='right'caption='[[1qjj]], [[Resolution|resolution]] 1.86Å' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1qjj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Astacus_astacus Astacus astacus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QJJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QJJ FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HOA:HYDROXYAMINE'>HOA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qjj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qjj OCA], [https://pdbe.org/1qjj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qjj RCSB], [https://www.ebi.ac.uk/pdbsum/1qjj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qjj ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ASTA_ASTAS ASTA_ASTAS] This protease prefers to cleave in front of small aliphatic residues (P1'). The presence of Lys or Arg in the P1 and P2 position yields high-turnover substrates. In the P3 position the enzyme prefers Pro > Val > Leu > Ala > Gly. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qj/1qjj_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qjj ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[Proteinase 3D structures|Proteinase 3D structures]] | |
| - | [ | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Astacus astacus]] | [[Category: Astacus astacus]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Synthetic construct]] |
| - | [[Category: | + | [[Category: Bode W]] |
| - | + | [[Category: Grams F]] | |
| - | [[Category: | + | [[Category: Stocker W]] |
| - | [[Category: | + | |
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Current revision
Structure of astacin with a hydroxamic acid inhibitor
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