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3ho5

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{{Seed}}
 
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[[Image:3ho5.png|left|200px]]
 
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==Crystal structure of Hedgehog-interacting protein (HHIP) and Sonic hedgehog (SHH) complex==
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The line below this paragraph, containing "STRUCTURE_3ho5", creates the "Structure Box" on the page.
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<StructureSection load='3ho5' size='340' side='right'caption='[[3ho5]], [[Resolution|resolution]] 3.01&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ho5]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HO5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HO5 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.01&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3ho5| PDB=3ho5 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ho5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ho5 OCA], [https://pdbe.org/3ho5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ho5 RCSB], [https://www.ebi.ac.uk/pdbsum/3ho5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ho5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HHIP_HUMAN HHIP_HUMAN] Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family.<ref>PMID:11472839</ref> <ref>PMID:19561609</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ho/3ho5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ho5 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Hedgehog (Hh) signaling is crucial for many aspects of embryonic development, whereas dysregulation of this pathway is associated with several types of cancer. Hedgehog-interacting protein (Hhip) is a surface receptor antagonist that is equipotent against all three mammalian Hh homologs. The crystal structures of human HHIP alone and bound to Sonic hedgehog (SHH) now reveal that HHIP is comprised of two EGF domains and a six-bladed beta-propeller domain. In the complex structure, a critical loop from HHIP binds the pseudo active site groove of SHH and directly coordinates its Zn2+ cation. Notably, sequence comparisons of this SHH binding loop with the Hh receptor Patched (Ptc1) ectodomains and HHIP- and PTC1-peptide binding studies suggest a 'patch for Patched' at the Shh pseudo active site; thus, we propose a role for Hhip as a structural decoy receptor for vertebrate Hh.
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===Crystal structure of Hedgehog-interacting protein (HHIP) and Sonic hedgehog (SHH) complex===
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The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.,Bosanac I, Maun HR, Scales SJ, Wen X, Lingel A, Bazan JF, de Sauvage FJ, Hymowitz SG, Lazarus RA Nat Struct Mol Biol. 2009 Jul;16(7):691-7. Epub 2009 Jun 28. PMID:19561609<ref>PMID:19561609</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3ho5" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19561609}}, adds the Publication Abstract to the page
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*[[Sonic hedgehog 3D structures|Sonic hedgehog 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19561609 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19561609}}
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__TOC__
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</StructureSection>
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==Disease==
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Known disease associated with this structure: Coloboma, ocular OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600725 600725]], Holoprosencephaly-3 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600725 600725]], Microphthalmia, isolated, with coloboma 5 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600725 600725]], Solitary median maxillary central incisor OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600725 600725]]
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==About this Structure==
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3HO5 is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HO5 OCA].
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==Reference==
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<ref group="xtra">PMID:19561609</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bosanac, I.]]
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[[Category: Large Structures]]
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[[Category: Hymowitz, S G.]]
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[[Category: Bosanac I]]
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[[Category: Alternative splicing]]
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[[Category: Hymowitz SG]]
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[[Category: Autocatalytic cleavage]]
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[[Category: Calcium cation]]
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[[Category: Cell membrane]]
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[[Category: Cytoplasm]]
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[[Category: Developmental protein]]
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[[Category: Disease mutation]]
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[[Category: Disulfide bond]]
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[[Category: Egf domain]]
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[[Category: Egf-like domain]]
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[[Category: Glycoprotein]]
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[[Category: Holoprosencephaly]]
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[[Category: Hydrolase]]
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[[Category: Lipoprotein]]
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[[Category: Membrane]]
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[[Category: Microphthalmia]]
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[[Category: Palmitate]]
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[[Category: Polymorphism]]
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[[Category: Protease]]
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[[Category: Receptor ectodomain]]
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[[Category: Secreted]]
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[[Category: Signaling protein]]
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[[Category: Six-bladed-propeller domain]]
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[[Category: Zinc cation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 28 10:48:23 2010''
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Current revision

Crystal structure of Hedgehog-interacting protein (HHIP) and Sonic hedgehog (SHH) complex

PDB ID 3ho5

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