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3lb6

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{{Seed}}
 
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[[Image:3lb6.png|left|200px]]
 
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==The structure of IL-13 in complex with IL-13Ralpha2==
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The line below this paragraph, containing "STRUCTURE_3lb6", creates the "Structure Box" on the page.
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<StructureSection load='3lb6' size='340' side='right'caption='[[3lb6]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3lb6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LB6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LB6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.05&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_3lb6| PDB=3lb6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lb6 OCA], [https://pdbe.org/3lb6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lb6 RCSB], [https://www.ebi.ac.uk/pdbsum/3lb6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lb6 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN] Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:[https://omim.org/entry/607154 607154]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure.
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== Function ==
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[https://www.uniprot.org/uniprot/IL13_HUMAN IL13_HUMAN] Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lb/3lb6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lb6 ConSurf].
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<div style="clear:both"></div>
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===The structure of IL-13 in complex with IL-13Ralpha2===
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==See Also==
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*[[Interleukin 3D structures|Interleukin 3D structures]]
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*[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]]
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 20223216 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20223216}}
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==About this Structure==
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3LB6 is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LB6 OCA].
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==Reference==
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<ref group="xtra">PMID:20223216</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Birnbaum, M E.]]
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[[Category: Large Structures]]
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[[Category: Garcia, K C.]]
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[[Category: Birnbaum ME]]
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[[Category: Lupardus, P J.]]
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[[Category: Garcia KC]]
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[[Category: Cytokine]]
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[[Category: Lupardus PJ]]
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[[Category: Decoy]]
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[[Category: Decoy receptor]]
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[[Category: Glycoprotein]]
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[[Category: Receptor]]
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[[Category: Secreted]]
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[[Category: Signaling protein-signaling protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 28 10:51:51 2010''
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Current revision

The structure of IL-13 in complex with IL-13Ralpha2

PDB ID 3lb6

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