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1qnx

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[[Image:1qnx.jpg|left|200px]]<br /><applet load="1qnx" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1qnx, resolution 1.90&Aring;" />
 
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'''VES V 5, AN ALLERGEN FROM VESPULA VULGARIS VENOM'''<br />
 
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==Overview==
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==Ves v 5, an allergen from Vespula vulgaris venom==
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Ves v 5 is one of three major allergens found in yellow-jacket venom:, phospholipase A(1) (Ves v 1), hyaluronidase (Ves v 2), and antigen 5 (Ves, v 5). Ves v 5 is related by high amino acid sequence identity to, pathogenesis-related proteins including proteins from mammals, reptiles, insects, fungi, and plants. The crystal structure of Ves v 5 has been, solved and refined to a resolution of 1.9 A. The majority of residues, conserved between the pathogenesis-related proteins can be rationalized in, terms of hydrogen bonding patterns and hydrophobic interactions defining, an alpha-beta-alpha sandwich core structure. A small number of consensus, residues are solvent exposed (including two adjacent histidines) and, located in an elongated cavity that forms a putative active site. The site, has no structural resemblance to previously characterized enzymes., Homologous antigen 5's from a large number of different yellow jackets, hornets, and paper wasps are known and patients show varying extents of, cross-reactivity to the related antigen 5's. The structure of Ves v 5, allows a detailed analysis of the epitopes that may participate in, antigenic cross-reactivity, findings that are useful for the development, of a vaccine for treatment of insect allergy.
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<StructureSection load='1qnx' size='340' side='right'caption='[[1qnx]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1qnx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vespula_vulgaris Vespula vulgaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QNX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QNX FirstGlance]. <br>
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1QNX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Vespula_vulgaris Vespula vulgaris] with NA as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=NA1:Na Binding Site For Residue A458'>NA1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QNX OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qnx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qnx OCA], [https://pdbe.org/1qnx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qnx RCSB], [https://www.ebi.ac.uk/pdbsum/1qnx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qnx ProSAT]</span></td></tr>
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Major venom allergen of yellow jackets, Ves v 5: structural characterization of a pathogenesis-related protein superfamily., Henriksen A, King TP, Mirza O, Monsalve RI, Meno K, Ipsen H, Larsen JN, Gajhede M, Spangfort MD, Proteins. 2001 Dec 1;45(4):438-48. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11746691 11746691]
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</table>
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[[Category: Single protein]]
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== Function ==
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[https://www.uniprot.org/uniprot/VA5_VESVU VA5_VESVU]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qn/1qnx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qnx ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Vespula vulgaris]]
[[Category: Vespula vulgaris]]
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[[Category: Gajhede, M.]]
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[[Category: Gajhede M]]
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[[Category: Henriksen, A.]]
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[[Category: Henriksen A]]
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[[Category: Spangfort, M.D.]]
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[[Category: Spangfort MD]]
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[[Category: NA]]
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[[Category: allergen]]
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[[Category: antigen 5]]
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[[Category: vespid venom]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 17:58:14 2007''
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Current revision

Ves v 5, an allergen from Vespula vulgaris venom

PDB ID 1qnx

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