3iyc

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{{Seed}}
 
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[[Image:3iyc.png|left|200px]]
 
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==Poliovirus late RNA-release intermediate==
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The line below this paragraph, containing "STRUCTURE_3iyc", creates the "Structure Box" on the page.
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<SX load='3iyc' size='340' side='right' viewer='molstar' caption='[[3iyc]], [[Resolution|resolution]] 10.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3iyc]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_poliovirus_1 Human poliovirus 1], [https://en.wikipedia.org/wiki/Human_poliovirus_1_Mahoney Human poliovirus 1 Mahoney] and [https://en.wikipedia.org/wiki/Poliovirus_type_3_(strains_P3/LEON/37_AND_P3/LEON_12A1B) Poliovirus type 3 (strains P3/LEON/37 AND P3/LEON 12A1B)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IYC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IYC FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 10&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iyc OCA], [https://pdbe.org/3iyc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iyc RCSB], [https://www.ebi.ac.uk/pdbsum/3iyc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iyc ProSAT]</span></td></tr>
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{{STRUCTURE_3iyc| PDB=3iyc | SCENE= }}
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</table>
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== Function ==
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===Poliovirus late RNA-release intermediate===
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[https://www.uniprot.org/uniprot/POLG_POL1M POLG_POL1M] Capsid proteins VP1, VP2, VP3 and VP4 form a closed capsid enclosing the viral positive strand RNA genome. VP4 lies on the inner surface of the protein shell formed by VP1, VP2 and VP3. All the three latter proteins contain a beta-sheet structure called beta-barrel jelly roll. Together they form an icosahedral capsid (T=3) composed of 60 copies of each VP1, VP2, and VP3, with a diameter of approximately 300 Angstroms. VP1 is situated at the 12 fivefold axes, whereas VP2 and VP3 are located at the quasi-sixfold axes. The interaction of five VP1 proteins in the fivefold axes results in a prominent protusion extending to about 25 Angstroms from the capsid shell. The resulting structure appears as a steep plateau encircled by a valley or cleft. This depression also termed canyon is the receptor binding site. The capsid interacts with human PVR at this site to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin- and caveolin-independent endocytosis in Hela cells and through caveolin-mediated endocytosis in brain microvascular endothelial cells. VP4 and VP1 subsequently undergo conformational changes leading to the formation of a pore in the endosomal membrane, thereby delivering the viral genome into the cytoplasm.<ref>PMID:9755863</ref> <ref>PMID:15919927</ref> <ref>PMID:18191571</ref> VP0 precursor is a component of immature procapsids (By similarity).<ref>PMID:9755863</ref> <ref>PMID:15919927</ref> <ref>PMID:18191571</ref> Protein 2A is a cysteine protease that is responsible for the cleavage between the P1 and P2 regions. It cleaves the host translation initiation factor EIF4G1, in order to shut down the capped cellular mRNA transcription.<ref>PMID:9755863</ref> <ref>PMID:15919927</ref> <ref>PMID:18191571</ref> Protein 2B affects membrane integrity and cause an increase in membrane permeability (By similarity).<ref>PMID:9755863</ref> <ref>PMID:15919927</ref> <ref>PMID:18191571</ref> Protein 2C associates with and induces structural rearrangements of intracellular membranes. It displays RNA-binding, nucleotide binding and NTPase activities.<ref>PMID:9755863</ref> <ref>PMID:15919927</ref> <ref>PMID:18191571</ref> Protein 3A, via its hydrophobic domain, serves as membrane anchor. It also inhibits endoplasmic reticulum-to-Golgi transport (By similarity).<ref>PMID:9755863</ref> <ref>PMID:15919927</ref> <ref>PMID:18191571</ref> Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).<ref>PMID:9755863</ref> <ref>PMID:15919927</ref> <ref>PMID:18191571</ref> RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).<ref>PMID:9755863</ref> <ref>PMID:15919927</ref> <ref>PMID:18191571</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_20181687}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 20181687 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iy/3iyc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_20181687}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3iyc ConSurf].
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3IYC is a 5 chains structure with sequences from [http://en.wikipedia.org/wiki/Human_poliovirus_1 Human poliovirus 1], [http://en.wikipedia.org/wiki/Human_poliovirus_1_mahoney Human poliovirus 1 mahoney] and [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IYC OCA].
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:20181687</ref><references group="xtra"/>
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__TOC__
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</SX>
[[Category: Human poliovirus 1]]
[[Category: Human poliovirus 1]]
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[[Category: Human poliovirus 1 mahoney]]
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[[Category: Human poliovirus 1 Mahoney]]
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[[Category: Viruses]]
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[[Category: Large Structures]]
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[[Category: Bostina, M.]]
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[[Category: Bostina M]]
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[[Category: Filman, D J.]]
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[[Category: Filman DJ]]
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[[Category: Hogle, J M.]]
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[[Category: Hogle JM]]
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[[Category: Levy, H C.]]
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[[Category: Levy HC]]
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[[Category: 80]]
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[[Category: Atp-binding]]
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[[Category: Capsid protein]]
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[[Category: Covalent protein-rna linkage]]
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[[Category: Cytoplasm]]
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[[Category: Cytoplasmic vesicle]]
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[[Category: Helicase]]
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[[Category: Host-virus interaction]]
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[[Category: Hydrolase]]
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[[Category: Intermediate]]
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[[Category: Lipoprotein]]
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[[Category: Membrane]]
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[[Category: Myristate]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleotidyltransferase]]
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[[Category: Phosphoprotein]]
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[[Category: Picornavirus]]
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[[Category: Poliovirus]]
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[[Category: Protease]]
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[[Category: Rna release]]
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[[Category: Rna replication]]
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[[Category: Rna-binding]]
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[[Category: Rna-directed rna polymerase]]
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[[Category: Thiol protease]]
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[[Category: Transferase]]
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[[Category: Viral protein]]
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[[Category: Virion]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 28 11:20:29 2010''
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Current revision

Poliovirus late RNA-release intermediate

3iyc, resolution 10.00Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

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