3kz4

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{{Seed}}
 
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[[Image:3kz4.png|left|200px]]
 
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==Crystal Structure of the Rotavirus Double Layered Particle==
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The line below this paragraph, containing "STRUCTURE_3kz4", creates the "Structure Box" on the page.
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<SX load='3kz4' size='340' side='right' viewer='molstar' caption='[[3kz4]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3kz4]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovine_rotavirus_strain_UK/G6 Bovine rotavirus strain UK/G6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KZ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KZ4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3kz4| PDB=3kz4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kz4 OCA], [https://pdbe.org/3kz4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kz4 RCSB], [https://www.ebi.ac.uk/pdbsum/3kz4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kz4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VP2_ROTBU VP2_ROTBU] Inner capsid protein that self-assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices. This capsid constitutes the innermost concentric layer of the viral mature particle (PubMed:20122940). It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core (PubMed:20122940). The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus (PubMed:20122940). Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels formed by VP2 N-termini (PubMed:20122940). VP2 is required for the replicase activity of VP1 polymerase (By similarity). Probably recruits a copy of a VP1-VP3 complex, potentially along with a segment of plus-strand RNA, as a decamer of VP2 assembles (PubMed:20122940). May activate the autoinhibited VP1/RNA complex to coordinate packaging and genome replication (By similarity).[HAMAP-Rule:MF_04127]<ref>PMID:20122940</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kz/3kz4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kz4 ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of the Rotavirus Double Layered Particle===
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==See Also==
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 20122940 is the PubMed ID number.
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</SX>
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[[Category: Bovine rotavirus strain UK/G6]]
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{{ABSTRACT_PUBMED_20122940}}
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[[Category: Large Structures]]
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[[Category: Bellamy AR]]
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==About this Structure==
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[[Category: Harrison SC]]
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3KZ4 is a 15 chains structure with sequences from [http://en.wikipedia.org/wiki/Bovine_rotavirus Bovine rotavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KZ4 OCA].
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[[Category: Mcclain B]]
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[[Category: Settembre EC]]
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==Reference==
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<ref group="xtra">PMID:20122940</ref><references group="xtra"/>
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[[Category: Bovine rotavirus]]
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[[Category: Bellamy, A R.]]
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[[Category: Harrison, S C.]]
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[[Category: Mcclain, B.]]
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[[Category: Settembre, E C.]]
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[[Category: Capsid]]
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[[Category: Core protein]]
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[[Category: Dsrna virus]]
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[[Category: Icosahedral virus]]
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[[Category: Metal-binding]]
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[[Category: Rna-binding]]
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[[Category: Rotavirus]]
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[[Category: Virion]]
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[[Category: Virus]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 28 11:22:10 2010''
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Current revision

Crystal Structure of the Rotavirus Double Layered Particle

3kz4, resolution 3.80Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

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