User:Yadilette Rivera-Colon/Sandbox1
From Proteopedia
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| + | A CBI Molecule being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst and on display at the Molecular Playground. | ||
===Human Lysosomal Protective Protein Cathepsin A (PPCA)=== | ===Human Lysosomal Protective Protein Cathepsin A (PPCA)=== | ||
[[Image:PPCA.jpg|frame|Human Lysosomal Protective Protein Cathepsin A]] | [[Image:PPCA.jpg|frame|Human Lysosomal Protective Protein Cathepsin A]] | ||
| - | The human protective protein cathepsin A forms a multi-enzyme complex with beta-galactosidase and neuraminidase in lysosomes. | + | The human protective protein cathepsin A forms a multi-enzyme complex with beta-galactosidase and neuraminidase in lysosomes. PPCA has so far two functions:a catalytic activity overlapping with that of Cathepsin A and a protective function towards lysosomal beta-galactosidase and neuraminidase. The stability and activity of the latter glycosidases depend on their interaction with PPCA [1]. |
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{{Clear}} | {{Clear}} | ||
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=== PPCA Glycosylation sites === | === PPCA Glycosylation sites === | ||
| + | PPCA, is synthesized as a 542 amino acid precursor with a molecular weight of 54kDa. and it dimerizes soon after synthesis. The sequence contains two glycosylation sites, Asn 117 and Asn 305. It also contains nine cysteines. The spinning protein (<scene name='User:Yadilette_Rivera-Colon/Sandbox1/Glycosylation_sites_ppca/1'>PPCA Glycosylation sites</scene> ) is human protective protein with the glycosylation sites represented in stick model colored by atom. | ||
| - | + | ===References: === | |
| - | + | [1] Jackman, H. L., Morris, P. W., Deddish, P. A., Skidgel, R. A. and Erdos, E. G. (1992) J. Biol. Chem. 267, 2872-2875 | |
Current revision
A CBI Molecule being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst and on display at the Molecular Playground.
Human Lysosomal Protective Protein Cathepsin A (PPCA)
The human protective protein cathepsin A forms a multi-enzyme complex with beta-galactosidase and neuraminidase in lysosomes. PPCA has so far two functions:a catalytic activity overlapping with that of Cathepsin A and a protective function towards lysosomal beta-galactosidase and neuraminidase. The stability and activity of the latter glycosidases depend on their interaction with PPCA [1].
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PPCA Glycosylation sites
PPCA, is synthesized as a 542 amino acid precursor with a molecular weight of 54kDa. and it dimerizes soon after synthesis. The sequence contains two glycosylation sites, Asn 117 and Asn 305. It also contains nine cysteines. The spinning protein ( ) is human protective protein with the glycosylation sites represented in stick model colored by atom.
References:
[1] Jackman, H. L., Morris, P. W., Deddish, P. A., Skidgel, R. A. and Erdos, E. G. (1992) J. Biol. Chem. 267, 2872-2875
