2wsb

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:10, 1 May 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2wsb.png|left|200px]]
 
-
<!--
+
==Crystal structure of the short-chain dehydrogenase Galactitol- Dehydrogenase (GatDH) of Rhodobacter sphaeroides in complex with NAD==
-
The line below this paragraph, containing "STRUCTURE_2wsb", creates the "Structure Box" on the page.
+
<StructureSection load='2wsb' size='340' side='right'caption='[[2wsb]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2wsb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Cereibacter_sphaeroides Cereibacter sphaeroides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WSB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WSB FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=POL:N-PROPANOL'>POL</scene></td></tr>
-
{{STRUCTURE_2wsb| PDB=2wsb | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wsb OCA], [https://pdbe.org/2wsb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wsb RCSB], [https://www.ebi.ac.uk/pdbsum/2wsb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wsb ProSAT]</span></td></tr>
-
 
+
</table>
-
===CRYSTAL STRUCTURE OF THE SHORT-CHAIN DEHYDROGENASE GALACTITOL-DEHYDROGENASE (GATDH) OF RHODOBACTER SPHAEROIDES IN COMPLEX WITH NAD===
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/GATDH_CERSP GATDH_CERSP] Catalyzes the interconversion of galactitol to the rare sugar L-tagatose (PubMed:7551050). Shows activity with a wide range of substrates, and catalyzes the oxidation of a variety of polyvalent aliphatic alcohols and polyols to the corresponding ketones and ketoses, respectively, and in the reverse reaction, it reduces ketones with high stereoselectivity yielding the corresponding S-configurated alcohols (PubMed:7551050, PubMed:15296184). Shows high activity with D-threitol, xylitol, 1,2-hexanediol, 1,2-pentanediol, 2-hexanol, L-erythrulose, D-ribulose and acetoin (PubMed:7551050). Specific for NAD(+) (PubMed:7551050).<ref>PMID:15296184</ref> <ref>PMID:7551050</ref>
-
 
+
== Evolutionary Conservation ==
-
<!--
+
[[Image:Consurf_key_small.gif|200px|right]]
-
The line below this paragraph, {{ABSTRACT_PUBMED_20410293}}, adds the Publication Abstract to the page
+
Check<jmol>
-
(as it appears on PubMed at http://www.pubmed.gov), where 20410293 is the PubMed ID number.
+
<jmolCheckbox>
-
-->
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ws/2wsb_consurf.spt"</scriptWhenChecked>
-
{{ABSTRACT_PUBMED_20410293}}
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
 
+
<text>to colour the structure by Evolutionary Conservation</text>
-
==About this Structure==
+
</jmolCheckbox>
-
2WSB is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Rhodobacter_sphaeroides Rhodobacter sphaeroides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WSB OCA].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wsb ConSurf].
-
 
+
<div style="clear:both"></div>
-
==Reference==
+
== References ==
-
<ref group="xtra">PMID:20410293</ref><references group="xtra"/>
+
<references/>
-
[[Category: Galactitol 2-dehydrogenase]]
+
__TOC__
-
[[Category: Rhodobacter sphaeroides]]
+
</StructureSection>
-
[[Category: Carius, Y.]]
+
[[Category: Cereibacter sphaeroides]]
-
[[Category: Christian, H.]]
+
[[Category: Large Structures]]
-
[[Category: Faust, A.]]
+
[[Category: Carius Y]]
-
[[Category: Giffhorn, F.]]
+
[[Category: Christian H]]
-
[[Category: Kohring, G W.]]
+
[[Category: Faust A]]
-
[[Category: Kornberger, P.]]
+
[[Category: Giffhorn F]]
-
[[Category: Scheidig, A J.]]
+
[[Category: Kohring GW]]
-
[[Category: Oxidoreductase]]
+
[[Category: Kornberger P]]
-
[[Category: Rossmann fold]]
+
[[Category: Scheidig AJ]]
-
[[Category: Sdr]]
+
-
[[Category: Tagatose]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 5 11:08:03 2010''
+

Current revision

Crystal structure of the short-chain dehydrogenase Galactitol- Dehydrogenase (GatDH) of Rhodobacter sphaeroides in complex with NAD

PDB ID 2wsb

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2wsb"
Personal tools