3mhh

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{{Seed}}
 
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[[Image:3mhh.png|left|200px]]
 
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==Structure of the SAGA Ubp8/Sgf11/Sus1/Sgf73 DUB module==
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The line below this paragraph, containing "STRUCTURE_3mhh", creates the "Structure Box" on the page.
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<StructureSection load='3mhh' size='340' side='right'caption='[[3mhh]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3mhh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MHH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MHH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3mhh| PDB=3mhh | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mhh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mhh OCA], [https://pdbe.org/3mhh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mhh RCSB], [https://www.ebi.ac.uk/pdbsum/3mhh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mhh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/UBP8_YEAST UBP8_YEAST] Functions as histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus. Together with SGF11, is required for histone H2B deubiquitination.<ref>PMID:10026213</ref> <ref>PMID:14660634</ref> <ref>PMID:15657441</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mh/3mhh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mhh ConSurf].
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<div style="clear:both"></div>
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===Structure of the SAGA Ubp8/Sgf11/Sus1/Sgf73 DUB module===
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==See Also==
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*[[SAGA-associated factor|SAGA-associated factor]]
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*[[Thioesterase 3D structures|Thioesterase 3D structures]]
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== References ==
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The line below this paragraph, {{ABSTRACT_PUBMED_20395473}}, adds the Publication Abstract to the page
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 20395473 is the PubMed ID number.
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__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_20395473}}
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[[Category: Large Structures]]
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==About this Structure==
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3MHH is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MHH OCA].
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==Reference==
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<ref group="xtra">PMID:20395473</ref><references group="xtra"/>
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Ubiquitin thiolesterase]]
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[[Category: Berndsen CE]]
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[[Category: Berndsen, C E.]]
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[[Category: Cohen RE]]
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[[Category: Cohen, R E.]]
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[[Category: Datta AB]]
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[[Category: Datta, A B.]]
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[[Category: Samara NL]]
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[[Category: Samara, N L.]]
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[[Category: Wolberger C]]
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[[Category: Wolberger, C.]]
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[[Category: Yao T]]
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[[Category: Yao, T.]]
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[[Category: Zhang X]]
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[[Category: Zhang, X.]]
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[[Category: Hydrolase-transcription complex]]
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[[Category: Multi-protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 5 11:12:19 2010''
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Current revision

Structure of the SAGA Ubp8/Sgf11/Sus1/Sgf73 DUB module

PDB ID 3mhh

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OCA

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