2krr

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{{Seed}}
 
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[[Image:2krr.jpg|left|200px]]
 
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==Solution structure of the RBD1,2 domains from human nucleolin==
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The line below this paragraph, containing "STRUCTURE_2krr", creates the "Structure Box" on the page.
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<StructureSection load='2krr' size='340' side='right'caption='[[2krr]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2krr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KRR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KRR FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2krr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2krr OCA], [https://pdbe.org/2krr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2krr RCSB], [https://www.ebi.ac.uk/pdbsum/2krr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2krr ProSAT]</span></td></tr>
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{{STRUCTURE_2krr| PDB=2krr | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NUCL_HUMAN NUCL_HUMAN] Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.<ref>PMID:10393184</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kr/2krr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2krr ConSurf].
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<div style="clear:both"></div>
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===Solution structure of the RBD1,2 domains from human nucleolin===
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==See Also==
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*[[Nucleolin|Nucleolin]]
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== References ==
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==About this Structure==
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<references/>
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2KRR is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KRR OCA].
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__TOC__
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:20376532</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arumugam, N.]]
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[[Category: Large Structures]]
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[[Category: Bates, P J.]]
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[[Category: Arumugam N]]
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[[Category: Lane, A N.]]
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[[Category: Bates PJ]]
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[[Category: Maliekal, J.]]
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[[Category: Lane AN]]
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[[Category: Miller, C.]]
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[[Category: Maliekal J]]
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[[Category: Trent, J O.]]
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[[Category: Miller C]]
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[[Category: Acetylation]]
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[[Category: Trent JO]]
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[[Category: Cytoplasm]]
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[[Category: Dna-binding]]
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[[Category: Methylation]]
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[[Category: Nuclear protein]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Rna-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 5 11:53:27 2010''
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Current revision

Solution structure of the RBD1,2 domains from human nucleolin

PDB ID 2krr

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