2kq7

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{{Seed}}
 
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[[Image:2kq7.jpg|left|200px]]
 
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==Solution structure of the Autophagy-Related Protein Atg8==
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The line below this paragraph, containing "STRUCTURE_2kq7", creates the "Structure Box" on the page.
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<StructureSection load='2kq7' size='340' side='right'caption='[[2kq7]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2kq7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KQ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KQ7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kq7 OCA], [https://pdbe.org/2kq7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kq7 RCSB], [https://www.ebi.ac.uk/pdbsum/2kq7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kq7 ProSAT]</span></td></tr>
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{{STRUCTURE_2kq7| PDB=2kq7 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ATG8_YEAST ATG8_YEAST] Involved in cytoplasm to vacuole transport (Cvt) vesicles and autophagosomes formation. With ATG4, may mediate the delivery of the vesicles and autophagosomes to the vacuole via the microtubule cytoskeleton. Participates also in membrane fusion events that take place in the early secretory pathway.<ref>PMID:8224160</ref> <ref>PMID:7593182</ref> <ref>PMID:9649430</ref> <ref>PMID:10525546</ref> <ref>PMID:10681575</ref> <ref>PMID:10837468</ref> <ref>PMID:11038174</ref> <ref>PMID:11100732</ref> <ref>PMID:11149920</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kq/2kq7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kq7 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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During autophagy a crescent shaped like membrane is formed, which engulfs the material that is to be degraded. This membrane grows further until its edges fuse to form the double membrane covered autophagosome. Atg8 is a protein, which is required for this initial step of autophagy. Therefore, a multistage conjugation process of newly synthesized Atg8 to phosphatidylethanolamine is of critical importance. Here we present the high resolution structure of unprocessed Atg8 determined by nuclear magnetic resonance spectroscopy. Its C-terminal subdomain shows a well-defined ubiquitin-like fold with slightly elevated mobility in the pico- to nanosecond timescale as determined by heteronuclear NOE data. In comparison to unprocessed Atg8, cleaved Atg8(G116) shows a decreased mobility behaviour. The N-terminal domain adopts different conformations within the micro- to millisecond timescale. The possible biological relevance of the differences in dynamic behaviours between both subdomains as well as between the cleaved and uncleaved forms is discussed.
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===Solution structure of the Autophagy-Related Protein Atg8===
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Solution structure of Atg8 reveals conformational polymorphism of the N-terminal domain.,Schwarten M, Stoldt M, Mohrluder J, Willbold D Biochem Biophys Res Commun. 2010 May 7;395(3):426-31. Epub 2010 Apr 9. PMID:20382112<ref>PMID:20382112</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2kq7" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_20382112}}, adds the Publication Abstract to the page
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*[[Autophagy-related protein 3D structures|Autophagy-related protein 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 20382112 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20382112}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2KQ7 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KQ7 OCA].
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==Reference==
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<ref group="xtra">PMID:20382112</ref><references group="xtra"/>
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Mohrluder, J.]]
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[[Category: Mohrluder J]]
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[[Category: Schwarten, M.]]
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[[Category: Schwarten M]]
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[[Category: Stoldt, M.]]
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[[Category: Stoldt M]]
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[[Category: Willbold, D.]]
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[[Category: Willbold D]]
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[[Category: Autophagy]]
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[[Category: Cytoplasmic vesicle]]
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[[Category: Lipoprotein]]
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[[Category: Membrane]]
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[[Category: Protein transport]]
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[[Category: Transport]]
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[[Category: Ubiquitin fold]]
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[[Category: Ubl conjugation pathway]]
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[[Category: Vacuole]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 5 11:55:36 2010''
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Current revision

Solution structure of the Autophagy-Related Protein Atg8

PDB ID 2kq7

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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