3m0b

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{{Seed}}
 
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[[Image:3m0b.png|left|200px]]
 
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==Ru-Porphyrin Protein Scaffolds for Sensing O2==
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The line below this paragraph, containing "STRUCTURE_3m0b", creates the "Structure Box" on the page.
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<StructureSection load='3m0b' size='340' side='right'caption='[[3m0b]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3m0b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caldanaerobacter_subterraneus_subsp._tengcongensis Caldanaerobacter subterraneus subsp. tengcongensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M0B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M0B FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=RUR:[3,3-(7,12-DIETHYL-3,8,13,17-TETRAMETHYLPORPHYRIN-2,18-DIYL-KAPPA~4~N~21~,N~22~,N~23~,N~24~)DIPROPANOATO(2-)]RUTHENIUM'>RUR</scene></td></tr>
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{{STRUCTURE_3m0b| PDB=3m0b | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m0b OCA], [https://pdbe.org/3m0b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m0b RCSB], [https://www.ebi.ac.uk/pdbsum/3m0b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m0b ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8RBX6_CALS4 Q8RBX6_CALS4]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m0/3m0b_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3m0b ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Hemoprotein-based scaffolds containing phosphorescent ruthenium(II) CO mesoporphyrin IX (RuMP) are reported here for oxygen (O(2)) sensing in biological contexts. RuMP was incorporated into the protein scaffolds during protein expression utilizing a novel method that we have described previously. A high-resolution (2.00 A) crystal structure revealed that the unnatural porphyrin binds to the proteins in a manner similar to the native heme and does not perturb the protein fold. The protein scaffolds were found to provide unique coordination environments for RuMP and modulate the porphyrin emission properties. Emission lifetime measurements demonstrate a linear O(2) response within the physiological range and precision comparable to commercial O(2) sensors. The RuMP proteins are robust, readily modifiable platforms and display promising O(2) sensing properties for future in vivo applications.
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===Ru-Porphyrin Protein Scaffolds for Sensing O2===
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Ru-porphyrin protein scaffolds for sensing O2.,Winter MB, McLaurin EJ, Reece SY, Olea C Jr, Nocera DG, Marletta MA J Am Chem Soc. 2010 Apr 28;132(16):5582-3. PMID:20373741<ref>PMID:20373741</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3m0b" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_20373741}}, adds the Publication Abstract to the page
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*[[Chemotaxis protein 3D structures|Chemotaxis protein 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 20373741 is the PubMed ID number.
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*[[Methyl-accepting chemotaxis protein|Methyl-accepting chemotaxis protein]]
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== References ==
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{{ABSTRACT_PUBMED_20373741}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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3M0B is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermoanaerobacter_tengcongensis Thermoanaerobacter tengcongensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M0B OCA].
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[[Category: Caldanaerobacter subterraneus subsp. tengcongensis]]
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[[Category: Large Structures]]
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==Reference==
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[[Category: Marletta MA]]
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<ref group="xtra">PMID:20373741</ref><references group="xtra"/>
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[[Category: McLaurin EJ]]
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[[Category: Thermoanaerobacter tengcongensis]]
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[[Category: Nocera DG]]
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[[Category: Jr., C Olea.]]
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[[Category: Olea Jr C]]
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[[Category: Marletta, M A.]]
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[[Category: Reece SY]]
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[[Category: McLaurin, E J.]]
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[[Category: Winter MB]]
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[[Category: Nocera, D G.]]
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[[Category: Reece, S Y.]]
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[[Category: Winter, M B.]]
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[[Category: Oxygen sensing molecule]]
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[[Category: Signaling protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 12 10:30:13 2010''
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Current revision

Ru-Porphyrin Protein Scaffolds for Sensing O2

PDB ID 3m0b

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