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3l8q

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{{Seed}}
 
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[[Image:3l8q.png|left|200px]]
 
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==Structure analysis of the type II cohesin dyad from the adaptor ScaA scaffoldin of Acetivibrio cellulolyticus==
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The line below this paragraph, containing "STRUCTURE_3l8q", creates the "Structure Box" on the page.
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<StructureSection load='3l8q' size='340' side='right'caption='[[3l8q]], [[Resolution|resolution]] 1.57&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3l8q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Acetivibrio_cellulolyticus Acetivibrio cellulolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L8Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L8Q FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.57&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene>, <scene name='pdbligand=PDO:1,3-PROPANDIOL'>PDO</scene></td></tr>
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{{STRUCTURE_3l8q| PDB=3l8q | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l8q OCA], [https://pdbe.org/3l8q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l8q RCSB], [https://www.ebi.ac.uk/pdbsum/3l8q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l8q ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q7WYN3_9FIRM Q7WYN3_9FIRM]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l8/3l8q_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3l8q ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The cellulosome complex is composed of a conglomerate of subunits, each of which comprises a set of interacting functional modules. Scaffoldin (Sca), a major cellulosomal subunit, is responsible for organizing the cellulolytic subunits into the complex. This is accomplished by the interaction of two complementary classes of modules-a cohesin (Coh) module on the Sca subunit and a dockerin module on each of the enzymatic subunits. Although individual Coh modules from different cellulosomal scaffoldins have been subjected to intensive structural investigation, the Sca subunit in its entirety has not, and there remains a paucity of information on the arrangement and interactions of Cohs within the Sca subunit. In the present work, we describe the crystal structure of a type II Coh dyad from the ScaB "adaptor" Sca of Acetivibrio cellulolyticus. The ScaB Cohs are oriented in an "antiparallel" manner relative to one another, with their dockerin-interacting surfaces (beta-strands 8-3-6-5) facing the same direction-aligned on the same plane. A set of extensive hydrophobic and hydrogen-bond contacts between the Cohs and the short interconnecting linker segment between them stabilizes the modular orientation. This Coh dyad structure provides novel information about Coh-Coh association and arrangement in the Sca and further insight into intermodular linker interactions. Putative structural arrangements of a hexamodular complex, composed of the Coh dyad bound to two X-dockerin modules, were suggested.
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===Structure analysis of the type II cohesin dyad from the adaptor ScaA scaffoldin of Acetivibrio cellulolyticus===
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Modular arrangement of a cellulosomal scaffoldin subunit revealed from the crystal structure of a cohesin dyad.,Noach I, Levy-Assaraf M, Lamed R, Shimon LJ, Frolow F, Bayer EA J Mol Biol. 2010 Jun 4;399(2):294-305. Epub 2010 Apr 13. PMID:20394754<ref>PMID:20394754</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_20394754}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3l8q" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 20394754 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20394754}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3L8Q is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Acetivibrio_cellulolyticus Acetivibrio cellulolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L8Q OCA].
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==Reference==
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<ref group="xtra">PMID:20394754</ref><ref group="xtra">PMID:19501595</ref><references group="xtra"/>
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[[Category: Acetivibrio cellulolyticus]]
[[Category: Acetivibrio cellulolyticus]]
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[[Category: Bayer, E A.]]
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[[Category: Large Structures]]
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[[Category: Frolow, F.]]
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[[Category: Bayer EA]]
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[[Category: Noach, I.]]
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[[Category: Frolow F]]
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[[Category: Alpha helix]]
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[[Category: Noach I]]
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[[Category: Beta flap]]
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[[Category: Beta sandwich]]
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[[Category: Dockerin-binding module]]
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[[Category: Linker segment]]
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[[Category: Protein binding]]
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[[Category: Protein-protein interaction]]
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[[Category: Scaffoldin arrangement]]
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[[Category: Structural protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 12 10:32:21 2010''
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Current revision

Structure analysis of the type II cohesin dyad from the adaptor ScaA scaffoldin of Acetivibrio cellulolyticus

PDB ID 3l8q

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