2xdg

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: '''Unreleased structure''' The entry 2xdg is ON HOLD Authors: PIKE, A.C.W., QUIGLEY, A., BARR, A.J., BURGESS BROWN, N., SHRESTHA, L., YANG, J., CHAIKUAD, A., VOLLMAR, M., MUNIZ, J.R.C.,...)
Current revision (08:04, 23 October 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 2xdg is ON HOLD
+
==Crystal structure of the extracellular domain of human growth hormone releasing hormone receptor.==
-
 
+
<StructureSection load='2xdg' size='340' side='right'caption='[[2xdg]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
-
Authors: PIKE, A.C.W., QUIGLEY, A., BARR, A.J., BURGESS BROWN, N., SHRESTHA, L., YANG, J., CHAIKUAD, A., VOLLMAR, M., MUNIZ, J.R.C., VON DELFT, F., EDWARDS, A., ARROWSMITH, C.H., WEIGELT, J., BOUNTRA, C., CARPENTER, E.P.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[2xdg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XDG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XDG FirstGlance]. <br>
-
Description: Crystal structure of the extracellular domain of human growth hormone releasing hormone receptor.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 12 10:40:35 2010''
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xdg OCA], [https://pdbe.org/2xdg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xdg RCSB], [https://www.ebi.ac.uk/pdbsum/2xdg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xdg ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/GHRHR_HUMAN GHRHR_HUMAN] Isolated growth hormone deficiency type IB. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:11232012</ref> <ref>PMID:10084571</ref> <ref>PMID:12534354</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/GHRHR_HUMAN GHRHR_HUMAN] Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xd/2xdg_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xdg ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Arrowsmith CH]]
 +
[[Category: Barr AJ]]
 +
[[Category: Bountra C]]
 +
[[Category: Burgess Brown N]]
 +
[[Category: Carpenter EP]]
 +
[[Category: Chaikuad A]]
 +
[[Category: Edwards A]]
 +
[[Category: Muniz JRC]]
 +
[[Category: Pike ACW]]
 +
[[Category: Quigley A]]
 +
[[Category: Shrestha L]]
 +
[[Category: Vollmar M]]
 +
[[Category: Weigelt J]]
 +
[[Category: Yang J]]
 +
[[Category: Von Delft F]]

Current revision

Crystal structure of the extracellular domain of human growth hormone releasing hormone receptor.

PDB ID 2xdg

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2xdg"
Personal tools