3lhr

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{{Seed}}
 
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[[Image:3lhr.jpg|left|200px]]
 
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==Crystal structure of the SCAN domain from Human ZNF24==
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The line below this paragraph, containing "STRUCTURE_3lhr", creates the "Structure Box" on the page.
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<StructureSection load='3lhr' size='340' side='right'caption='[[3lhr]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3lhr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LHR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LHR FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EMC:ETHYL+MERCURY+ION'>EMC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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{{STRUCTURE_3lhr| PDB=3lhr | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lhr OCA], [https://pdbe.org/3lhr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lhr RCSB], [https://www.ebi.ac.uk/pdbsum/3lhr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lhr ProSAT]</span></td></tr>
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</table>
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===Crystal structure of the SCAN domain from Human ZNF24===
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== Function ==
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[https://www.uniprot.org/uniprot/ZNF24_HUMAN ZNF24_HUMAN] Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro.<ref>PMID:10585455</ref>
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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3LHR is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LHR OCA].
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lh/3lhr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lhr ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bingman, C A.]]
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[[Category: Large Structures]]
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[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
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[[Category: Bingman CA]]
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[[Category: Peterson, F C.]]
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[[Category: Peterson FC]]
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[[Category: Phillips, G N.]]
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[[Category: Phillips Jr GN]]
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[[Category: Volkman, B F.]]
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[[Category: Volkman BF]]
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[[Category: Center for eukaryotic structural genomic]]
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[[Category: Cesg]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Repressor]]
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[[Category: Scan domain]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Transcription regulator]]
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[[Category: Ubl conjugation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 12 11:18:51 2010''
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Current revision

Crystal structure of the SCAN domain from Human ZNF24

PDB ID 3lhr

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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