This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3ipk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:55, 6 September 2023) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3ipk.png|left|200px]]
 
-
<!--
+
==Crystal Structure of A3VP1 of AgI/II of Streptococcus mutans==
-
The line below this paragraph, containing "STRUCTURE_3ipk", creates the "Structure Box" on the page.
+
<StructureSection load='3ipk' size='340' side='right'caption='[[3ipk]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3ipk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_mutans Streptococcus mutans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IPK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IPK FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.04&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PMS:PHENYLMETHANESULFONIC+ACID'>PMS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
{{STRUCTURE_3ipk| PDB=3ipk | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ipk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ipk OCA], [https://pdbe.org/3ipk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ipk RCSB], [https://www.ebi.ac.uk/pdbsum/3ipk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ipk ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/C9E3B4_STRMG C9E3B4_STRMG]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ip/3ipk_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ipk ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Streptococcus mutans antigen I/II (AgI/II) is a cell surface-localized protein adhesin that interacts with salivary components within the salivary pellicle. AgI/II contributes to virulence and has been studied as an immunological and structural target, but a fundamental understanding of its underlying architecture has been lacking. Here we report a high-resolution (1.8 A) crystal structure of the A(3)VP(1) fragment of S. mutans AgI/II that demonstrates a unique fibrillar form (155 A) through the interaction of two noncontiguous regions in the primary sequence. The A(3) repeat of the alanine-rich domain adopts an extended alpha-helix that intertwines with the P(1) repeat polyproline type II (PPII) helix to form a highly extended stalk-like structure heretofore unseen in prokaryotic or eukaryotic protein structures. Velocity sedimentation studies indicate that full-length AgI/II that contains three A/P repeats extends over 50 nanometers in length. Isothermal titration calorimetry revealed that the high-affinity association between the A(3) and P(1) helices is enthalpically driven. Two distinct binding sites on AgI/II to the host receptor salivary agglutinin (SAG) were identified by surface plasmon resonance (SPR). The current crystal structure reveals that AgI/II family proteins are extended fibrillar structures with the number of alanine- and proline-rich repeats determining their length.
-
===Crystal Structure of A3VP1 of AgI/II of Streptococcus mutans===
+
Elongated fibrillar structure of a streptococcal adhesin assembled by the high-affinity association of {alpha}- and PPII-helices.,Larson MR, Rajashankar KR, Patel MH, Robinette RA, Crowley PJ, Michalek S, Brady LJ, Deivanayagam C Proc Natl Acad Sci U S A. 2010 Mar 15. PMID:20231452<ref>PMID:20231452</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_20231452}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 3ipk" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 20231452 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_20231452}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
3IPK is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Streptococcus_mutans Streptococcus mutans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IPK OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:20231452</ref><references group="xtra"/>
+
[[Category: Streptococcus mutans]]
[[Category: Streptococcus mutans]]
-
[[Category: Brady, L J.]]
+
[[Category: Brady LJ]]
-
[[Category: Crowley, P.]]
+
[[Category: Crowley P]]
-
[[Category: Deivanayagam, C C.]]
+
[[Category: Deivanayagam CC]]
-
[[Category: Larson, M R.]]
+
[[Category: Larson MR]]
-
[[Category: Michalek, S M.]]
+
[[Category: Michalek SM]]
-
[[Category: Patel, M.]]
+
[[Category: Patel M]]
-
[[Category: Rajashankar, K R.]]
+
[[Category: Rajashankar KR]]
-
[[Category: Robinette, R.]]
+
[[Category: Robinette R]]
-
[[Category: Alpha helix]]
+
-
[[Category: Cell adhesion]]
+
-
[[Category: Cell wall]]
+
-
[[Category: Peptidoglycan-anchor]]
+
-
[[Category: Ppii helix]]
+
-
[[Category: Supersandwich fold]]
+
-
[[Category: Surface adhesin]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 20 09:00:10 2010''
+

Current revision

Crystal Structure of A3VP1 of AgI/II of Streptococcus mutans

PDB ID 3ipk

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3ipk"
Personal tools