3m3r

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{{Seed}}
 
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[[Image:3m3r.png|left|200px]]
 
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==Crystal structure of the M113F alpha-hemolysin mutant complexed with beta-cyclodextrin==
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The line below this paragraph, containing "STRUCTURE_3m3r", creates the "Structure Box" on the page.
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<StructureSection load='3m3r' size='340' side='right'caption='[[3m3r]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3m3r]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M3R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M3R FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900012:beta-cyclodextrin'>PRD_900012</scene></td></tr>
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{{STRUCTURE_3m3r| PDB=3m3r | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m3r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m3r OCA], [https://pdbe.org/3m3r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m3r RCSB], [https://www.ebi.ac.uk/pdbsum/3m3r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m3r ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HLA_STAAU HLA_STAAU] Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m3/3m3r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3m3r ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the M113F alpha-hemolysin mutant complexed with beta-cyclodextrin===
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==See Also==
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*[[Hemolysin 3D structures|Hemolysin 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_20400691}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 20400691 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20400691}}
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==About this Structure==
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3M3R is a 7 chains structure with sequences from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M3R OCA].
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==Reference==
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<ref group="xtra">PMID:20400691</ref><references group="xtra"/>
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[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: Gouaux, E.]]
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[[Category: Gouaux E]]
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[[Category: Montoya, M.]]
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[[Category: Montoya M]]
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[[Category: Beta barrel]]
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[[Category: Cell invasion]]
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[[Category: Cytolysis]]
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[[Category: Cytolytic protein]]
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[[Category: Hemolysis]]
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[[Category: Secreted]]
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[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 20 09:04:55 2010''
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Current revision

Crystal structure of the M113F alpha-hemolysin mutant complexed with beta-cyclodextrin

PDB ID 3m3r

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