3m8e

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'''Unreleased structure'''
 
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The entry 3m8e is ON HOLD until Paper Publication
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==Protein structure of Type III plasmid segregation TubR==
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<StructureSection load='3m8e' size='340' side='right'caption='[[3m8e]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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Authors: Ni, L., Schumacher, M.A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3m8e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_thuringiensis_serovar_israelensis Bacillus thuringiensis serovar israelensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M8E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M8E FirstGlance]. <br>
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Description: Protein structure of Type III plasmid segregation TubR
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m8e OCA], [https://pdbe.org/3m8e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m8e RCSB], [https://www.ebi.ac.uk/pdbsum/3m8e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m8e ProSAT]</span></td></tr>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 20 09:16:59 2010''
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TUBR_BACTI TUBR_BACTI] A DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid. Cooperatively binds to the centromere-like site (tubC), which may seed filament formation by the TubZ polymerizing GTPase, stabilizing TubZ filaments. TubR-tubC complexes track the depolymerizing minus end of the filament, probably pulling plasmid within the cell (PubMed:20534443, PubMed:23010931, PubMed:25825718). Required for plasmid replication (PubMed:16936050, PubMed:17873046). Negatively regulates levels of TubZ; its effect on RNA expression has not been shown (Probable). Specifically binds iterons, 12-bp imperfect direct repeats that function as a plasmid origin of replication (PubMed:17873046, PubMed:23010931, PubMed:25825718). Four TubR dimers bind to tubC, forming an extended bent DNA-protein filament with protein wrapping helically around the outside of the DNA (PubMed:20534443, PubMed:23010931).<ref>PMID:16936050</ref> <ref>PMID:17873046</ref> <ref>PMID:20534443</ref> <ref>PMID:23010931</ref> <ref>PMID:25825718</ref> <ref>PMID:17510284</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Bacillus thuringiensis serovar israelensis]]
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[[Category: Large Structures]]
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[[Category: Ni L]]
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[[Category: Schumacher MA]]

Current revision

Protein structure of Type III plasmid segregation TubR

PDB ID 3m8e

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