3mqm

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{{Seed}}
 
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[[Image:3mqm.jpg|left|200px]]
 
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==Crystal Structure of the Bromodomain of human ASH1L==
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The line below this paragraph, containing "STRUCTURE_3mqm", creates the "Structure Box" on the page.
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<StructureSection load='3mqm' size='340' side='right'caption='[[3mqm]], [[Resolution|resolution]] 2.54&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3mqm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MQM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MQM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.54&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mqm OCA], [https://pdbe.org/3mqm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mqm RCSB], [https://www.ebi.ac.uk/pdbsum/3mqm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mqm ProSAT]</span></td></tr>
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{{STRUCTURE_3mqm| PDB=3mqm | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ASH1L_HUMAN ASH1L_HUMAN] Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me).<ref>PMID:21239497</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mq/3mqm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mqm ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Bromodomains (BRDs) are protein interaction modules that specifically recognize epsilon-N-lysine acetylation motifs, a key event in the reading process of epigenetic marks. The 61 BRDs in the human genome cluster into eight families based on structure/sequence similarity. Here, we present 29 high-resolution crystal structures, covering all BRD families. Comprehensive crossfamily structural analysis identifies conserved and family-specific structural features that are necessary for specific acetylation-dependent substrate recognition. Screening of more than 30 representative BRDs against systematic histone-peptide arrays identifies new BRD substrates and reveals a strong influence of flanking posttranslational modifications, such as acetylation and phosphorylation, suggesting that BRDs recognize combinations of marks rather than singly acetylated sequences. We further uncovered a structural mechanism for the simultaneous binding and recognition of diverse diacetyl-containing peptides by BRD4. These data provide a foundation for structure-based drug design of specific inhibitors for this emerging target family.
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===Crystal Structure of the Bromodomain of human ASH1L===
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Histone recognition and large-scale structural analysis of the human bromodomain family.,Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Muller S, Pawson T, Gingras AC, Arrowsmith CH, Knapp S Cell. 2012 Mar 30;149(1):214-31. PMID:22464331<ref>PMID:22464331</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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3MQM is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MQM OCA].
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<div class="pdbe-citations 3mqm" style="background-color:#fffaf0;"></div>
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[[Category: Histone-lysine N-methyltransferase]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bountra, C.]]
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[[Category: Arrowsmith CH]]
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[[Category: Canning, P.]]
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[[Category: Bountra C]]
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[[Category: Chaikuad, A.]]
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[[Category: Canning P]]
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[[Category: Delft, F von.]]
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[[Category: Chaikuad A]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards AM]]
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[[Category: Felletar, I.]]
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[[Category: Felletar I]]
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[[Category: Filippakopoulos, P.]]
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[[Category: Filippakopoulos P]]
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[[Category: Keates, T.]]
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[[Category: Keates T]]
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[[Category: Knapp, S.]]
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[[Category: Knapp S]]
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[[Category: Krojer, T.]]
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[[Category: Krojer T]]
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[[Category: Picaud, S.]]
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[[Category: Picaud S]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Vollmar M]]
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[[Category: Vollmar, M.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Von Delft F]]
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[[Category: Absent small and homeotic disks protein 1 homolog]]
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[[Category: Ash1]]
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[[Category: Ash1l]]
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[[Category: Kiaa1420]]
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[[Category: Kmt2h]]
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[[Category: Lysine n-methyltransferase 2h]]
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[[Category: Sgc]]
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[[Category: Structural genomics consortium]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 20 09:51:22 2010''
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Current revision

Crystal Structure of the Bromodomain of human ASH1L

PDB ID 3mqm

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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