2kxs
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==ZO1 ZU5 domain in complex with GRINL1A peptide== | |
| - | + | <StructureSection load='2kxs' size='340' side='right'caption='[[2kxs]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2kxs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KXS FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kxs OCA], [https://pdbe.org/2kxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kxs RCSB], [https://www.ebi.ac.uk/pdbsum/2kxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kxs ProSAT]</span></td></tr> | |
| - | '' | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref> [https://www.uniprot.org/uniprot/MYZAP_HUMAN MYZAP_HUMAN] Plays a role in cellular signaling via Rho-related GTP-binding proteins and subsequent activation of transcription factor SRF (By similarity). Targets TJP1 to cell junctions. In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity). | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Wen W]] | ||
| + | [[Category: Zhang M]] | ||
Current revision
ZO1 ZU5 domain in complex with GRINL1A peptide
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