3lw9

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{{Seed}}
 
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[[Image:3lw9.jpg|left|200px]]
 
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==Structure of a Cytoplasmic Domain of Salmonella InvA==
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The line below this paragraph, containing "STRUCTURE_3lw9", creates the "Structure Box" on the page.
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<StructureSection load='3lw9' size='340' side='right'caption='[[3lw9]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3lw9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LW9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LW9 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3lw9| PDB=3lw9 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lw9 OCA], [https://pdbe.org/3lw9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lw9 RCSB], [https://www.ebi.ac.uk/pdbsum/3lw9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lw9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/INVA_SALTY INVA_SALTY] Involved in the invasion of the cells of the intestinal epithelium. Could be involved in the translocation of the InvE protein.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lw/3lw9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lw9 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Protein type III secretion systems (T3SSs) are organic nanosyringes that achieve an energy-dependent translocation of bacterial proteins through the two membranes of Gram-negative organisms. Examples include the pathogenic systems of animals, plants and symbiotic bacteria that inject factors into eukaryotic cells, and the flagellar export system that secretes flagellin. T3SSs possess a core of several membrane-associated proteins that are conserved across all known bacterial species that use this system. The Salmonella protein InvA is one of the most highly conserved proteins of this core of critical T3SS components. The crystal structure of a C-terminal domain of InvA reveals an unexpected homology to domains that have been repeatedly found as building blocks of other elements of the T3SS apparatus. This suggests the surprising hypothesis that evolution has produced a significant component of the apparatus structure through a series of gene-duplication and gene-rearrangement events.
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===Structure of a Cytoplasmic Domain of Salmonella InvA===
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A conserved domain in type III secretion links the cytoplasmic domain of InvA to elements of the basal body.,Lilic M, Quezada CM, Stebbins CE Acta Crystallogr D Biol Crystallogr. 2010 Jun;66(Pt 6):709-13. Epub 2010 May 15. PMID:20516623<ref>PMID:20516623</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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3LW9 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LW9 OCA].
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<div class="pdbe-citations 3lw9" style="background-color:#fffaf0;"></div>
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[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
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== References ==
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[[Category: Lilic, M.]]
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<references/>
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[[Category: Quezada, C M.]]
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__TOC__
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[[Category: Stebbins, C E.]]
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</StructureSection>
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[[Category: Bacterial pathogenesis]]
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[[Category: Large Structures]]
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[[Category: Cell inner membrane]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
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[[Category: Cell membrane]]
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[[Category: Lilic M]]
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[[Category: Inva]]
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[[Category: Quezada CM]]
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[[Category: Membrane]]
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[[Category: Stebbins CE]]
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[[Category: Protein transport]]
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[[Category: Salmonella]]
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[[Category: Transmembrane]]
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[[Category: Transport]]
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[[Category: Type iii secretion]]
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[[Category: Virulence]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 26 08:33:44 2010''
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Current revision

Structure of a Cytoplasmic Domain of Salmonella InvA

PDB ID 3lw9

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