2jw6

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{{Seed}}
 
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[[Image:2jw6.png|left|200px]]
 
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==Solution structure of the DEAF1 MYND domain==
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The line below this paragraph, containing "STRUCTURE_2jw6", creates the "Structure Box" on the page.
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<StructureSection load='2jw6' size='340' side='right'caption='[[2jw6]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2jw6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2fv6 2fv6]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JW6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JW6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2jw6| PDB=2jw6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jw6 OCA], [https://pdbe.org/2jw6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jw6 RCSB], [https://www.ebi.ac.uk/pdbsum/2jw6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jw6 ProSAT]</span></td></tr>
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</table>
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===Solution structure of the DEAF1 MYND domain===
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== Function ==
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[https://www.uniprot.org/uniprot/DEAF1_HUMAN DEAF1_HUMAN] Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Required for neural tube closure and skeletal patterning. Regulates epithelial cell proliferation and side-branching in the mammary gland. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 4. Isoform 4 may inhibit transcriptional activity of isoform 1 by interacting with isoform 1 and retaining it in the cytoplasm.<ref>PMID:11705868</ref> <ref>PMID:19668219</ref> <ref>PMID:10521432</ref> <ref>PMID:11427895</ref> <ref>PMID:18826651</ref>
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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2JW6 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2fv6 2fv6]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JW6 OCA].
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Check<jmol>
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<jmolCheckbox>
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==Reference==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jw/2jw6_consurf.spt"</scriptWhenChecked>
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<ref group="xtra">PMID:16527309</ref><references group="xtra"/>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jw6 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ansieu, S.]]
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[[Category: Large Structures]]
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[[Category: Bottomley, M.]]
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[[Category: Ansieu S]]
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[[Category: Perrin, H.]]
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[[Category: Bottomley M]]
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[[Category: Sattler, M.]]
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[[Category: Perrin H]]
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[[Category: Spadaccini, R.]]
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[[Category: Sattler M]]
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[[Category: Alternative splicing]]
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[[Category: Spadaccini R]]
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[[Category: Disease mutation]]
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[[Category: Dna-binding]]
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[[Category: Metal-binding]]
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[[Category: Nucleus]]
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[[Category: Phosphorylation]]
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[[Category: Secreted]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Zinc binding domain]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 26 08:36:47 2010''
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Current revision

Solution structure of the DEAF1 MYND domain

PDB ID 2jw6

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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