3l8i

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{{Seed}}
 
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[[Image:3l8i.png|left|200px]]
 
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==Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity==
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The line below this paragraph, containing "STRUCTURE_3l8i", creates the "Structure Box" on the page.
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<StructureSection load='3l8i' size='340' side='right'caption='[[3l8i]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3l8i]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L8I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L8I FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l8i OCA], [https://pdbe.org/3l8i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l8i RCSB], [https://www.ebi.ac.uk/pdbsum/3l8i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l8i ProSAT]</span></td></tr>
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{{STRUCTURE_3l8i| PDB=3l8i | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/PDC10_HUMAN PDC10_HUMAN] Hereditary cerebral cavernous malformation. Defects in PDCD10 are the cause of cerebral cavernous malformations type 3 (CCM3) [MIM:[https://omim.org/entry/603285 603285]. Cerebral cavernous malformations (CCMs) are congenital vascular anomalies of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. CCMs have an incidence of 0.1%-0.5% in the general population and usually present clinically during the 3rd to 5th decade of life. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters.<ref>PMID:15543491</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/PDC10_HUMAN PDC10_HUMAN] Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and MST4 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity).<ref>PMID:15543491</ref> <ref>PMID:17360971</ref> <ref>PMID:20332113</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l8/3l8i_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3l8i ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity===
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==See Also==
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*[[Cell death protein 3D structures|Cell death protein 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 20489202 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_20489202}}
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==About this Structure==
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3L8I is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L8I OCA].
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==Reference==
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<ref group="xtra">PMID:20489202</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Boggon, T J.]]
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[[Category: Large Structures]]
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[[Category: He, Y.]]
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[[Category: Boggon TJ]]
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[[Category: Ji, W.]]
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[[Category: He Y]]
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[[Category: Li, X.]]
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[[Category: Ji W]]
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[[Category: Min, W.]]
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[[Category: Li X]]
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[[Category: Zhang, H.]]
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[[Category: Min W]]
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[[Category: Zhang, R.]]
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[[Category: Zhang H]]
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[[Category: Cerebral cavernous malformation]]
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[[Category: Zhang R]]
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[[Category: Dimerization]]
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[[Category: Fat domain]]
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[[Category: Protein binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 2 08:24:54 2010''
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Current revision

Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity

PDB ID 3l8i

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OCA

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