3lkk

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{{Seed}}
 
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[[Image:3lkk.jpg|left|200px]]
 
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==Crystal structure of the isopentenyl phosphate kinase substrate complex==
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The line below this paragraph, containing "STRUCTURE_3lkk", creates the "Structure Box" on the page.
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<StructureSection load='3lkk' size='340' side='right'caption='[[3lkk]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3lkk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoplasma_acidophilum_DSM_1728 Thermoplasma acidophilum DSM 1728]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LKK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.001&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=IP8:ISOPENTENYL+PHOSPHATE'>IP8</scene></td></tr>
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{{STRUCTURE_3lkk| PDB=3lkk | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lkk OCA], [https://pdbe.org/3lkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lkk RCSB], [https://www.ebi.ac.uk/pdbsum/3lkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lkk ProSAT]</span></td></tr>
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</table>
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===Crystal structure of the isopentenyl phosphate kinase substrate complex===
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== Function ==
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[https://www.uniprot.org/uniprot/IPK_THEAC IPK_THEAC] Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. Has lower activity with isopentenyl thiolophosphate (ISP). Has low activity with dimethylallyl phosphate (DMAP), 1-butyl phosphate (BP) and 3-buten-1-yl phosphate (BEP). Has no significant activity with geranyl phosphate (in vitro).<ref>PMID:19928876</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 20402538 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lk/3lkk_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_20402538}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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3LKK is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LKK OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lkk ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:20402538</ref><references group="xtra"/>
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<references/>
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[[Category: Thermoplasma acidophilum]]
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__TOC__
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[[Category: Hill, C P.]]
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</StructureSection>
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[[Category: Mabanglo, M F.]]
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[[Category: Large Structures]]
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[[Category: Alpha-beta-alpha sandwich fold]]
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[[Category: Thermoplasma acidophilum DSM 1728]]
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[[Category: Alternate mevalonate pathway]]
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[[Category: Hill CP]]
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[[Category: Isopentenyl phosphate kinase]]
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[[Category: Mabanglo MF]]
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[[Category: Kinase]]
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[[Category: Substrate complex]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 2 08:35:27 2010''
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Current revision

Crystal structure of the isopentenyl phosphate kinase substrate complex

PDB ID 3lkk

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