3n1r

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{{Seed}}
 
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[[Image:3n1r.jpg|left|200px]]
 
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==Crystal Structure of ShhN==
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The line below this paragraph, containing "STRUCTURE_3n1r", creates the "Structure Box" on the page.
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<StructureSection load='3n1r' size='340' side='right'caption='[[3n1r]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3n1r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N1R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N1R FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.13&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3n1r| PDB=3n1r | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n1r OCA], [https://pdbe.org/3n1r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n1r RCSB], [https://www.ebi.ac.uk/pdbsum/3n1r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n1r ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SHH_MOUSE SHH_MOUSE] Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction (By similarity).<ref>PMID:7736596</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n1/3n1r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n1r ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of ShhN===
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==See Also==
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*[[Sonic hedgehog 3D structures|Sonic hedgehog 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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3N1R is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N1R OCA].
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Kavran, J M.]]
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[[Category: Kavran JM]]
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[[Category: Leahy, D J.]]
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[[Category: Leahy DJ]]
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[[Category: Binding site]]
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[[Category: Calcium]]
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[[Category: Cell adhesion molecule]]
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[[Category: Cell cycle protein]]
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[[Category: Cell line]]
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[[Category: Cell surface]]
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[[Category: Conserved sequence]]
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[[Category: Fibronectin]]
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[[Category: Hedgehog protein]]
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[[Category: Immunoglobulin g]]
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[[Category: Membrane glycoprotein]]
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[[Category: Membrane protein]]
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[[Category: Protein binding]]
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[[Category: Receptor]]
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[[Category: Sequence homology]]
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[[Category: Signal transduction]]
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[[Category: Tertiary]]
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[[Category: Tumor suppressor protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 2 08:41:01 2010''
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Current revision

Crystal Structure of ShhN

PDB ID 3n1r

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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