3n8i
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3n8i is ON HOLD Authors: Homan, K.T., Balasubramaniam, D., Stauffacher, C.V. Description: Crystal structure of the A isoform of human cytoplasmic p...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the A isoform of human cytoplasmic protein tyrosine phosphatase (HCPTP-A) in complex with 1-naphtylacetic acid== | |
| - | + | <StructureSection load='3n8i' size='340' side='right'caption='[[3n8i]], [[Resolution|resolution]] 1.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3n8i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N8I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N8I FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NLA:NAPHTHALEN-1-YL-ACETIC+ACID'>NLA</scene></td></tr> | |
| - | '' | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n8i OCA], [https://pdbe.org/3n8i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n8i RCSB], [https://www.ebi.ac.uk/pdbsum/3n8i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n8i ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PPAC_HUMAN PPAC_HUMAN] Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Balasubramaniam D]] | ||
| + | [[Category: Homan KT]] | ||
| + | [[Category: Stauffacher CV]] | ||
Current revision
Crystal structure of the A isoform of human cytoplasmic protein tyrosine phosphatase (HCPTP-A) in complex with 1-naphtylacetic acid
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