2ktu

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{{Seed}}
 
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[[Image:2ktu.jpg|left|200px]]
 
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==Human eRF1 C-domain, "closed" conformer==
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The line below this paragraph, containing "STRUCTURE_2ktu", creates the "Structure Box" on the page.
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<StructureSection load='2ktu' size='340' side='right'caption='[[2ktu]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ktu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KTU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KTU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ktu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ktu OCA], [https://pdbe.org/2ktu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ktu RCSB], [https://www.ebi.ac.uk/pdbsum/2ktu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ktu ProSAT]</span></td></tr>
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{{STRUCTURE_2ktu| PDB=2ktu | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ERF1_HUMAN ERF1_HUMAN] Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.<ref>PMID:7990965</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kt/2ktu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ktu ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We report NMR assignments of the protein backbone of the C-terminal domain (163 a.a.) of human class 1 translation termination factor eRF1. It was found that several protein loop residues exist in two slowly interconverting conformational states.
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===Human eRF1 C-domain, "closed" conformer===
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NMR assignments of the C-terminal domain of human polypeptide release factor eRF1.,Mantsyzov AB, Ivanova EV, Birdsall B, Kolosov PM, Kisselev LL, Polshakov VI Biomol NMR Assign. 2007 Dec;1(2):183-5. Epub 2007 Oct 30. PMID:19636860<ref>PMID:19636860</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19636860}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2ktu" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19636860 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19636860}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2KTU is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KTU OCA].
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==Reference==
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<ref group="xtra">PMID:19636860</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Birdsall, B.]]
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[[Category: Large Structures]]
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[[Category: Mantsyzov, A B.]]
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[[Category: Birdsall B]]
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[[Category: Polshakov, V I.]]
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[[Category: Mantsyzov AB]]
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[[Category: C domain]]
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[[Category: Polshakov VI]]
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[[Category: Cytoplasm]]
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[[Category: Erf1]]
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[[Category: Eukaryote]]
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[[Category: Protein biosynthesis]]
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[[Category: Termination]]
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[[Category: Translation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 10 11:02:46 2010''
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Current revision

Human eRF1 C-domain, "closed" conformer

PDB ID 2ktu

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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