2kkr

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{{Seed}}
 
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[[Image:2kkr.jpg|left|200px]]
 
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==Solution structure of SCA7 zinc finger domain from human ataxin-7 protein==
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The line below this paragraph, containing "STRUCTURE_2kkr", creates the "Structure Box" on the page.
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<StructureSection load='2kkr' size='340' side='right'caption='[[2kkr]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2kkr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KKR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KKR FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2kkr| PDB=2kkr | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kkr OCA], [https://pdbe.org/2kkr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kkr RCSB], [https://www.ebi.ac.uk/pdbsum/2kkr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kkr ProSAT]</span></td></tr>
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</table>
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===Solution structure of SCA7 zinc finger domain from human ataxin-7 protein===
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== Disease ==
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[https://www.uniprot.org/uniprot/ATX7_HUMAN ATX7_HUMAN] Spinocerebellar ataxia type 7. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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==About this Structure==
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[https://www.uniprot.org/uniprot/ATX7_HUMAN ATX7_HUMAN] Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary for microtubule cytoskeleton stabilization.<ref>PMID:22100762</ref>
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2KKR is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KKR OCA].
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kk/2kkr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kkr ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Atkinson, A R.]]
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[[Category: Large Structures]]
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[[Category: Bonnet, J.]]
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[[Category: Atkinson AR]]
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[[Category: Kieffer, B.]]
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[[Category: Bonnet J]]
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[[Category: Romier, C.]]
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[[Category: Kieffer B]]
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[[Category: Wang, Y.]]
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[[Category: Romier C]]
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[[Category: Protein binding]]
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[[Category: Wang Y]]
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[[Category: Spine]]
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[[Category: Structural genomic]]
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[[Category: Structural proteomics in europe]]
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[[Category: Transcription]]
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[[Category: Zinc finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 10 11:10:52 2010''
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Current revision

Solution structure of SCA7 zinc finger domain from human ataxin-7 protein

PDB ID 2kkr

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