2xdp

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{{Seed}}
 
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[[Image:2xdp.jpg|left|200px]]
 
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==Crystal structure of the tudor domain of human JMJD2C==
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The line below this paragraph, containing "STRUCTURE_2xdp", creates the "Structure Box" on the page.
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<StructureSection load='2xdp' size='340' side='right'caption='[[2xdp]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2xdp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XDP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XDP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2xdp| PDB=2xdp | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xdp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xdp OCA], [https://pdbe.org/2xdp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xdp RCSB], [https://www.ebi.ac.uk/pdbsum/2xdp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xdp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KDM4C_HUMAN KDM4C_HUMAN] Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xd/2xdp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xdp ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF THE TUDOR DOMAIN OF HUMAN JMJD2C===
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==See Also==
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*[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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2XDP is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XDP OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Allerston, C.]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C.]]
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[[Category: Allerston C]]
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[[Category: Bountra, C.]]
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[[Category: Arrowsmith C]]
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[[Category: Chaikuad, A.]]
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[[Category: Bountra C]]
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[[Category: Daniel, M.]]
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[[Category: Chaikuad A]]
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[[Category: Edwards, A.]]
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[[Category: Daniel M]]
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[[Category: Gileadi, C.]]
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[[Category: Edwards A]]
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[[Category: Krojer, T.]]
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[[Category: Gileadi C]]
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[[Category: Oppermann, U.]]
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[[Category: Krojer T]]
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[[Category: Phillips, C.]]
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[[Category: Oppermann U]]
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[[Category: Ugochukwu, E.]]
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[[Category: Phillips C]]
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[[Category: Vondelft, F.]]
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[[Category: Ugochukwu E]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Weisbach, H.]]
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[[Category: Weisbach H]]
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[[Category: Yue, W W.]]
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[[Category: Yue WW]]
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[[Category: Histone modification]]
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[[Category: Von Delft F]]
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[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 10 11:13:12 2010''
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Current revision

Crystal structure of the tudor domain of human JMJD2C

PDB ID 2xdp

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OCA

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