3n1m

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{{Seed}}
 
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[[Image:3n1m.png|left|200px]]
 
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==Crystal Structure of IhhN bound to BOCFn3==
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The line below this paragraph, containing "STRUCTURE_3n1m", creates the "Structure Box" on the page.
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<StructureSection load='3n1m' size='340' side='right'caption='[[3n1m]], [[Resolution|resolution]] 1.69&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3n1m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N1M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N1M FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.69&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3n1m| PDB=3n1m | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n1m OCA], [https://pdbe.org/3n1m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n1m RCSB], [https://www.ebi.ac.uk/pdbsum/3n1m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n1m ProSAT]</span></td></tr>
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</table>
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===Crystal Structure of IhhN bound to BOCFn3===
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== Disease ==
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[https://www.uniprot.org/uniprot/IHH_HUMAN IHH_HUMAN] Brachydactyly type A1;Acrocapitofemoral dysplasia. Defects in IHH are the cause of brachydactyly type A1 (BDA1) [MIM:[https://omim.org/entry/112500 112500]. BDA1 is an autosomal dominant disorder characterized by middle phalanges of all the digits rudimentary or fused with the terminal phalanges. The proximal phalanges of the thumbs and big toes are short.<ref>PMID:11455389</ref> <ref>PMID:12384778</ref> Defects in IHH are a cause of acrocapitofemoral dysplasia (ACFD) [MIM:[https://omim.org/entry/607778 607778]. ACFD is a disorder characterized by short stature of variable severity with postnatal onset. The most constant radiographic abnormalities are observed in the tubular bones of the hands and in the proximal part of the femur. Cone-shaped epiphyses or a similar epiphyseal configuration with premature epimetaphyseal fusion result in shortening of the skeletal components involved. Cone-shaped epiphyses were also present to a variable extent at the shoulders, knees, and ankles.<ref>PMID:12632327</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/IHH_HUMAN IHH_HUMAN] Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP) (By similarity).
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== Evolutionary Conservation ==
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(as it appears on PubMed at http://www.pubmed.gov), where 20519495 is the PubMed ID number.
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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{{ABSTRACT_PUBMED_20519495}}
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n1/3n1m_consurf.spt"</scriptWhenChecked>
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==Disease==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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Known disease associated with this structure: Acrocapitofemoral dysplasia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600726 600726]], Brachydactyly, type A1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600726 600726]]
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n1m ConSurf].
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3N1M is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N1M OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:20519495</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Kavran, J M.]]
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[[Category: Large Structures]]
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[[Category: Leahy, D J.]]
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[[Category: Kavran JM]]
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[[Category: Binding site]]
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[[Category: Leahy DJ]]
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[[Category: Calcium]]
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[[Category: Cell adhesion molecule]]
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[[Category: Cell cycle protein]]
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[[Category: Cell line]]
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[[Category: Cell surface]]
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[[Category: Conserved sequence]]
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[[Category: Fibronectin]]
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[[Category: Hedgehog protein]]
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[[Category: Immunoglobulin g]]
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[[Category: Membrane glycoprotein]]
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[[Category: Membrane protein]]
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[[Category: Protein binding]]
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[[Category: Receptor]]
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[[Category: Sequence homology]]
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[[Category: Signal transduction]]
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[[Category: Tertiary]]
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[[Category: Tumor suppressor protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 16 07:47:57 2010''
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Current revision

Crystal Structure of IhhN bound to BOCFn3

PDB ID 3n1m

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