2buj

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[[Image:2buj.gif|left|200px]]<br /><applet load="2buj" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2buj, resolution 2.60&Aring;" />
 
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'''CRYSTAL STRUCTURE OF THE HUMAN SERINE-THREONINE KINASE 16 IN COMPLEX WITH STAUROSPORINE'''<br />
 
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==About this Structure==
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==Crystal structure of the human Serine-threonine Kinase 16 in complex with staurosporine==
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2BUJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CL and STU as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Transferred_entry:_2.7.11.1 Transferred entry: 2.7.11.1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.37 2.7.1.37] Known structural/functional Site: <scene name='pdbsite=AC1:Stu Binding Site For Chain B'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BUJ OCA].
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<StructureSection load='2buj' size='340' side='right'caption='[[2buj]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[2buj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BUJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BUJ FirstGlance]. <br>
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[[Category: Transferred entry: 2.7.11.1]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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[[Category: Amos, A.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=STU:STAUROSPORINE'>STU</scene></td></tr>
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[[Category: Arrowsmith, C.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2buj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2buj OCA], [https://pdbe.org/2buj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2buj RCSB], [https://www.ebi.ac.uk/pdbsum/2buj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2buj ProSAT]</span></td></tr>
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[[Category: Ball, L.J.]]
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</table>
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[[Category: Bullock, A.]]
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== Function ==
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[[Category: Debreczeni, J.E.]]
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[https://www.uniprot.org/uniprot/STK16_HUMAN STK16_HUMAN] Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins.<ref>PMID:10364453</ref>
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[[Category: Delft, F.Von.]]
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== Evolutionary Conservation ==
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[[Category: Edwards, A.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Eswaran, J.]]
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Check<jmol>
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[[Category: Fedorov, O.]]
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<jmolCheckbox>
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[[Category: Filippakopoulos, P.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bu/2buj_consurf.spt"</scriptWhenChecked>
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[[Category: Kavanagh, K.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Knapp, S.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Sobott, F.]]
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</jmolCheckbox>
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[[Category: Sundstrom, M.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2buj ConSurf].
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[[Category: CL]]
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<div style="clear:both"></div>
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[[Category: STU]]
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[[Category: atp-binding]]
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[[Category: kinase]]
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[[Category: lipoprotein]]
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[[Category: myristate]]
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[[Category: palmitate]]
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[[Category: phosphorylation]]
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[[Category: serine/threonine-protein kinase]]
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[[Category: transferase]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 18:58:54 2007''
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==See Also==
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*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Amos A]]
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[[Category: Arrowsmith C]]
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[[Category: Ball LJ]]
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[[Category: Bullock A]]
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[[Category: Debreczeni JE]]
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[[Category: Edwards A]]
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[[Category: Eswaran J]]
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[[Category: Fedorov O]]
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[[Category: Filippakopoulos P]]
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[[Category: Kavanagh K]]
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[[Category: Knapp S]]
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[[Category: Sobott F]]
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[[Category: Sundstrom M]]
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[[Category: Von Delft F]]

Current revision

Crystal structure of the human Serine-threonine Kinase 16 in complex with staurosporine

PDB ID 2buj

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