3mop

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{{Seed}}
 
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[[Image:3mop.png|left|200px]]
 
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==The ternary Death Domain complex of MyD88, IRAK4, and IRAK2==
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The line below this paragraph, containing "STRUCTURE_3mop", creates the "Structure Box" on the page.
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<StructureSection load='3mop' size='340' side='right'caption='[[3mop]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3mop]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MOP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MOP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mop OCA], [https://pdbe.org/3mop PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mop RCSB], [https://www.ebi.ac.uk/pdbsum/3mop PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mop ProSAT]</span></td></tr>
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{{STRUCTURE_3mop| PDB=3mop | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/MYD88_HUMAN MYD88_HUMAN] Defects in MYD88 are the cause of MYD88 deficiency (MYD88D) [MIM:[https://omim.org/entry/612260 612260]; also known as recurrent pyogenic bacterial infections due to MYD88 deficiency. Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age.<ref>PMID:19506249</ref> <ref>PMID:18669862</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/MYD88_HUMAN MYD88_HUMAN] Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity).<ref>PMID:9013863</ref> <ref>PMID:15361868</ref> <ref>PMID:18292575</ref> <ref>PMID:19506249</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mo/3mop_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mop ConSurf].
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<div style="clear:both"></div>
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===The ternary Death Domain complex of MyD88, IRAK4, and IRAK2===
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==See Also==
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*[[Interleukin-1 receptor-associated kinase|Interleukin-1 receptor-associated kinase]]
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*[[TIR domain-containing adapter protein|TIR domain-containing adapter protein]]
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== References ==
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The line below this paragraph, {{ABSTRACT_PUBMED_20485341}}, adds the Publication Abstract to the page
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 20485341 is the PubMed ID number.
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__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_20485341}}
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==About this Structure==
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3MOP is a 14 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MOP OCA].
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==Reference==
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<ref group="xtra">PMID:20485341</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Large Structures]]
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[[Category: Lin, S C.]]
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[[Category: Lin S-C]]
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[[Category: Lo, Y C.]]
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[[Category: Lo Y-C]]
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[[Category: Wu, H.]]
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[[Category: Wu H]]
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[[Category: Death domain complex]]
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[[Category: Helical symmetry]]
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[[Category: Immune system]]
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[[Category: Left-handed helical assembly]]
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[[Category: Signaling protein]]
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[[Category: Single-stranded helical assembly]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 23 08:35:21 2010''
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Current revision

The ternary Death Domain complex of MyD88, IRAK4, and IRAK2

PDB ID 3mop

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OCA

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