3mmp

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{{Seed}}
 
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[[Image:3mmp.png|left|200px]]
 
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==Structure of the Qb replicase, an RNA-dependent RNA polymerase consisting of viral and host proteins==
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The line below this paragraph, containing "STRUCTURE_3mmp", creates the "Structure Box" on the page.
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<StructureSection load='3mmp' size='340' side='right'caption='[[3mmp]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3mmp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Escherichia_virus_Qbeta Escherichia virus Qbeta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MMP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PXN:(2S)-1-[3-{[(2R)-2-HYDROXYPROPYL]OXY}-2,2-BIS({[(2R)-2-HYDROXYPROPYL]OXY}METHYL)PROPOXY]PROPAN-2-OL'>PXN</scene></td></tr>
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{{STRUCTURE_3mmp| PDB=3mmp | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mmp OCA], [https://pdbe.org/3mmp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mmp RCSB], [https://www.ebi.ac.uk/pdbsum/3mmp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mmp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RDRP_BPQBE RDRP_BPQBE] This enzyme is part of the viral RNA-dependent RNA polymerase complex.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mm/3mmp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mmp ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The RNA-dependent RNA polymerase core complex formed upon infection of Escherichia coli by the bacteriophage Qbeta is composed of the viral catalytic beta-subunit as well as the host translation elongation factors EF-Tu and EF-Ts, which are required for initiation of RNA replication. We have determined the crystal structure of the complex between the beta-subunit and the two host proteins to 2.5-A resolution. Whereas the basic catalytic machinery in the viral subunit appears similar to other RNA-dependent RNA polymerases, a unique C-terminal region of the beta-subunit engages in extensive interactions with EF-Tu and may contribute to the separation of the transient duplex formed between the template and the nascent product to allow exponential amplification of the phage genome. The evolution of resistance by the host appears to be impaired because of the interactions of the beta-subunit with parts of EF-Tu essential in recognition of aminoacyl-tRNA.
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===Structure of the Qb replicase, an RNA-dependent RNA polymerase consisting of viral and host proteins===
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Structure of the Qbeta replicase, an RNA-dependent RNA polymerase consisting of viral and host proteins.,Kidmose RT, Vasiliev NN, Chetverin AB, Andersen GR, Knudsen CR Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):10884-9. Epub 2010 Jun 1. PMID:20534494<ref>PMID:20534494</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3mmp" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_20534494}}, adds the Publication Abstract to the page
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*[[Elongation factor 3D structures|Elongation factor 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 20534494 is the PubMed ID number.
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
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== References ==
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{{ABSTRACT_PUBMED_20534494}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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3MMP is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Enterobacteria_phage_qbeta Enterobacteria phage qbeta] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MMP OCA].
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[[Category: Escherichia coli K-12]]
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[[Category: Escherichia virus Qbeta]]
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==Reference==
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[[Category: Large Structures]]
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<ref group="xtra">PMID:20534494</ref><references group="xtra"/>
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[[Category: Andersen GR]]
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[[Category: Enterobacteria phage qbeta]]
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[[Category: Chetverin AB]]
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[[Category: Escherichia coli]]
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[[Category: Kidmose RT]]
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[[Category: RNA-directed RNA polymerase]]
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[[Category: Knudsen CR]]
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[[Category: Andersen, G R.]]
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[[Category: Vasiliev NN]]
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[[Category: Chetverin, A B.]]
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[[Category: Kidmose, R T.]]
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[[Category: Knudsen, C R.]]
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[[Category: Vasiliev, N N.]]
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[[Category: Host-factor complex]]
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[[Category: Rdrp]]
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[[Category: Transferase]]
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[[Category: Translation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 23 08:38:18 2010''
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Current revision

Structure of the Qb replicase, an RNA-dependent RNA polymerase consisting of viral and host proteins

PDB ID 3mmp

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OCA

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