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2kmi

From Proteopedia

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{{Seed}}
 
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[[Image:2kmi.jpg|left|200px]]
 
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==MESD(12-155), The Core Structural Domain of MESD that Is Essential for Proper Folding of LRP5/6==
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The line below this paragraph, containing "STRUCTURE_2kmi", creates the "Structure Box" on the page.
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<StructureSection load='2kmi' size='340' side='right'caption='[[2kmi]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2kmi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KMI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KMI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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-->
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kmi OCA], [https://pdbe.org/2kmi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kmi RCSB], [https://www.ebi.ac.uk/pdbsum/2kmi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kmi ProSAT]</span></td></tr>
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{{STRUCTURE_2kmi| PDB=2kmi | SCENE= }}
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</table>
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== Function ==
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===MESD(12-155), The Core Structural Domain of MESD that Is Essential for Proper Folding of LRP5/6===
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[https://www.uniprot.org/uniprot/MESD_MOUSE MESD_MOUSE] Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.<ref>PMID:12581525</ref> <ref>PMID:21397183</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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2KMI is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KMI OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/km/2kmi_consurf.spt"</scriptWhenChecked>
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==Reference==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<ref group="xtra">PMID:20506034</ref><ref group="xtra">PMID:12581519</ref><references group="xtra"/>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kmi ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Chen, J.]]
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[[Category: Chen J]]
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[[Category: Wang, J.]]
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[[Category: Wang J]]
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[[Category: Chaperone]]
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[[Category: Lrp5/6]]
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[[Category: Mesd/boca]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 23 08:46:17 2010''
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Current revision

MESD(12-155), The Core Structural Domain of MESD that Is Essential for Proper Folding of LRP5/6

PDB ID 2kmi

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