3ldi

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{{Seed}}
 
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[[Image:3ldi.jpg|left|200px]]
 
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==Crystal structure of aprotinin in complex with sucrose octasulfate: unusual interactions and implication for heparin binding==
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The line below this paragraph, containing "STRUCTURE_3ldi", creates the "Structure Box" on the page.
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<StructureSection load='3ldi' size='340' side='right'caption='[[3ldi]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ldi]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LDI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LDI FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3ldi| PDB=3ldi | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ldi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ldi OCA], [https://pdbe.org/3ldi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ldi RCSB], [https://www.ebi.ac.uk/pdbsum/3ldi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ldi ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BPT1_BOVIN BPT1_BOVIN] Inhibits trypsin, kallikrein, chymotrypsin, and plasmin.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ld/3ldi_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ldi ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structures of aprotinin and its complex with sucrose octasulfate (SOS), a polysulfated heparin analog, were determined at 1.7-2.6A resolutions. Aprotinin is monomeric in solution, which associates into a decamer at high salt concentrations. Sulfate ions serve to neutralize the basic amino acid residues of aprotinin to stabilize the decameric aprotinin. Whereas SOS interacts with heparin binding proteins at 1:1 molar ratio, SOS was surprisingly found to induce strong agglutination of aprotinins. Five molecules of aprotinin interact with one molecule of the sulfated sugar, which is stabilized by electrostatic interactions between the positively charged residues of aprotinin and sulfate groups of SOS. The multiple binding modes of SOS with five individual aprotinin molecules may represent the diverse patterns of potential heparin binding to aprotinin, reflecting the interactions of densely packed protein molecules along the heparin polymer.
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===Crystal structure of aprotinin in complex with sucrose octasulfate: unusual interactions and implication for heparin binding===
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Crystal structures of aprotinin and its complex with sucrose octasulfate reveal multiple modes of interactions with implications for heparin binding.,Yang IS, Kim TG, Park BS, Cho KJ, Lee JH, Park Y, Kim KH Biochem Biophys Res Commun. 2010 Jul 2;397(3):429-35. Epub 2010 May 27. PMID:20529698<ref>PMID:20529698</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3ldi" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_20529698}}, adds the Publication Abstract to the page
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*[[BPTI 3D structures|BPTI 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 20529698 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20529698}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3LDI is a 5 chains structure with sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LDI OCA].
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==Reference==
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<ref group="xtra">PMID:20529698</ref><references group="xtra"/>
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Kim, K H.]]
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[[Category: Large Structures]]
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[[Category: Kim, T G.]]
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[[Category: Kim KH]]
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[[Category: Park, B S.]]
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[[Category: Kim TG]]
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[[Category: Yang, I S.]]
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[[Category: Park BS]]
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[[Category: Aprotinin]]
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[[Category: Yang IS]]
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[[Category: Disulfide bond]]
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[[Category: Hydrolase inhibitor]]
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[[Category: Pharmaceutical]]
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[[Category: Protease inhibitor]]
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[[Category: Secreted]]
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[[Category: Serine protease inhibitor]]
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[[Category: Sucrose octasulfate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 23 08:50:10 2010''
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Current revision

Crystal structure of aprotinin in complex with sucrose octasulfate: unusual interactions and implication for heparin binding

PDB ID 3ldi

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