2fu4

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{{Seed}}
 
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[[Image:2fu4.png|left|200px]]
 
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==Crystal Structure of the DNA binding domain of E.coli FUR (Ferric Uptake Regulator)==
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The line below this paragraph, containing "STRUCTURE_2fu4", creates the "Structure Box" on the page.
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<StructureSection load='2fu4' size='340' side='right'caption='[[2fu4]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2fu4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21 Escherichia coli BL21]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FU4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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{{STRUCTURE_2fu4| PDB=2fu4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fu4 OCA], [https://pdbe.org/2fu4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fu4 RCSB], [https://www.ebi.ac.uk/pdbsum/2fu4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fu4 ProSAT]</span></td></tr>
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</table>
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===Crystal Structure of the DNA binding domain of E.coli FUR (Ferric Uptake Regulator)===
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== Function ==
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[https://www.uniprot.org/uniprot/FUR_ECOLI FUR_ECOLI] Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes. Regulates the expression of several outer-membrane proteins including the iron transport operon.<ref>PMID:2823881</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 16690618 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fu/2fu4_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_16690618}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2FU4 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FU4 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fu4 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:16690618</ref><references group="xtra"/>
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<references/>
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[[Category: Escherichia coli]]
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__TOC__
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[[Category: Autreaux, B D.]]
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</StructureSection>
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[[Category: Bersch, B.]]
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[[Category: Escherichia coli BL21]]
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[[Category: Brutscher, B.]]
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[[Category: Large Structures]]
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[[Category: Dupuy, J.]]
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[[Category: Bersch B]]
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[[Category: Jacquamet, L.]]
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[[Category: Brutscher B]]
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[[Category: Michaud-Soret, I.]]
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[[Category: D'Autreaux B]]
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[[Category: Nicolet, Y.]]
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[[Category: Dupuy J]]
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[[Category: Pecqueur, L.]]
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[[Category: Jacquamet L]]
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[[Category: Dna binding domain]]
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[[Category: Michaud-Soret I]]
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[[Category: Dna binding protein]]
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[[Category: Nicolet Y]]
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[[Category: Helix-turn-helix]]
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[[Category: Pecqueur L]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 30 13:19:18 2010''
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Current revision

Crystal Structure of the DNA binding domain of E.coli FUR (Ferric Uptake Regulator)

PDB ID 2fu4

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