3nlt

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(New page: '''Unreleased structure''' The entry 3nlt is ON HOLD Authors: Xue, F., Li, H. , Fang, J., Delker, S.L., Poulos, T.L., Silverman, R.B Description: Structure of endothelial nitric oxide ...)
Current revision (10:01, 14 February 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 3nlt is ON HOLD
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==Structure of endothelial nitric oxide synthase heme domain complexed with N1-{(3'S,4'S)-4'-[(6"-amino-4"-methylpyridin-2"-yl)methyl]pyrrolidin-3'-yl}- N2-(3'-fluorophenethyl)ethane-1,2-diamine tetrahydrochloride==
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<StructureSection load='3nlt' size='340' side='right'caption='[[3nlt]], [[Resolution|resolution]] 2.74&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3nlt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NLT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NLT FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.74&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3XF:6-({(3S,4S)-4-[2-({2,2-DIFLUORO-2-[(2R)-PIPERIDIN-2-YL]ETHYL}AMINO)ETHOXY]PYRROLIDIN-3-YL}METHYL)-4-METHYLPYRIDIN-2-AMINE'>3XF</scene>, <scene name='pdbligand=CAD:CACODYLIC+ACID'>CAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nlt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nlt OCA], [https://pdbe.org/3nlt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nlt RCSB], [https://www.ebi.ac.uk/pdbsum/3nlt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nlt ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NOS3_BOVIN NOS3_BOVIN] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
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Authors: Xue, F., Li, H. , Fang, J., Delker, S.L., Poulos, T.L., Silverman, R.B
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==See Also==
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*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
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Description: Structure of endothelial nitric oxide synthase heme domain complexed with N1-{(3'R,4'S)-4'-[(6"-amino-4"-methylpyridin-2"-yl)methyl]pyrrolidin-3'-yl}-N2-(3'-fluorophenethyl)ethane-1,2-diamine tetrahydrochloride
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__TOC__
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</StructureSection>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 30 13:36:57 2010''
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[[Category: Bos taurus]]
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[[Category: Large Structures]]
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[[Category: Delker SL]]
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[[Category: Fang J]]
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[[Category: Li H]]
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[[Category: Poulos TL]]
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[[Category: Silverman RB]]
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[[Category: Xue F]]

Current revision

Structure of endothelial nitric oxide synthase heme domain complexed with N1-{(3'S,4'S)-4'-[(6"-amino-4"-methylpyridin-2"-yl)methyl]pyrrolidin-3'-yl}- N2-(3'-fluorophenethyl)ethane-1,2-diamine tetrahydrochloride

PDB ID 3nlt

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