3jqk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (16:04, 1 November 2023) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3jqk.jpg|left|200px]]
 
-
<!--
+
==Crystal structure of the molybdenum cofactor biosynthesis protein C (TTHA1789) from Thermus Theromophilus HB8 (H32 FORM)==
-
The line below this paragraph, containing "STRUCTURE_3jqk", creates the "Structure Box" on the page.
+
<StructureSection load='3jqk' size='340' side='right'caption='[[3jqk]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3jqk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JQK FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-
{{STRUCTURE_3jqk| PDB=3jqk | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jqk OCA], [https://pdbe.org/3jqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jqk RCSB], [https://www.ebi.ac.uk/pdbsum/3jqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jqk ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q5SHE1_THET8 Q5SHE1_THET8] Together with MoaA, is involved in the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity).[HAMAP-Rule:MF_01224][SAAS:SAAS002820_004_012265]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jq/3jqk_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jqk ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The first step in the molybdenum cofactor (Moco) biosynthesis pathway involves the conversion of guanosine triphosphate (GTP) to precursor Z by two proteins (MoaA and MoaC). MoaA belongs to the S-adenosylmethionine-dependent radical enzyme superfamily and is believed to generate protein and/or substrate radicals by reductive cleavage of S-adenosylmethionine using an Fe-S cluster. MoaC has been suggested to catalyze the release of pyrophosphate and the formation of the cyclic phosphate of precursor Z. However, structural evidence showing the binding of a substrate-like molecule to MoaC is not available. Here, apo and GTP-bound crystal structures of MoaC from Thermus thermophilus HB8 are reported. Furthermore, isothermal titration calorimetry experiments have been carried out in order to obtain thermodynamic parameters for the protein-ligand interactions. In addition, molecular-dynamics (MD) simulations have been carried out on the protein-ligand complex of known structure and on models of relevant complexes for which X-ray structures are not available. The biophysical, structural and MD results reveal the residues that are involved in substrate binding and help in speculating upon a possible mechanism.
-
===Crystal structure of the molybdenum cofactor biosynthesis protein C (TTHA1789) from Thermus Theromophilus HB8 (H32 FORM)===
+
Structures of apo and GTP-bound molybdenum cofactor biosynthesis protein MoaC from Thermus thermophilus HB8.,Kanaujia SP, Jeyakanthan J, Nakagawa N, Balasubramaniam S, Shinkai A, Kuramitsu S, Yokoyama S, Sekar K Acta Crystallogr D Biol Crystallogr. 2010 Jul;66(Pt 7):821-33. Epub 2010 Jun 19. PMID:20606263<ref>PMID:20606263</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
==About this Structure==
+
</div>
-
3JQK is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JQK OCA].
+
<div class="pdbe-citations 3jqk" style="background-color:#fffaf0;"></div>
-
[[Category: Thermus thermophilus]]
+
== References ==
-
[[Category: Baba, S.]]
+
<references/>
-
[[Category: Chen, L.]]
+
__TOC__
-
[[Category: Ebihara, A.]]
+
</StructureSection>
-
[[Category: Jeyakanthan, J.]]
+
[[Category: Large Structures]]
-
[[Category: Kanaujia, S P.]]
+
[[Category: Thermus thermophilus HB8]]
-
[[Category: Kuramitsu, S.]]
+
[[Category: Baba S]]
-
[[Category: Liu, Z J.]]
+
[[Category: Chen L]]
-
[[Category: Nakagawa, N.]]
+
[[Category: Ebihara A]]
-
[[Category: Rsgi, Riken Structural Genomics/Proteomics Initiative.]]
+
[[Category: Jeyakanthan J]]
-
[[Category: Sekar, K.]]
+
[[Category: Kanaujia SP]]
-
[[Category: Shinkai, A.]]
+
[[Category: Kuramitsu S]]
-
[[Category: Shiro, Y.]]
+
[[Category: Liu Z-J]]
-
[[Category: Wang, B C.]]
+
[[Category: Nakagawa N]]
-
[[Category: Yokoyama, S.]]
+
[[Category: Sekar K]]
-
[[Category: Biosynthetic protein]]
+
[[Category: Shinkai A]]
-
[[Category: Moac]]
+
[[Category: Shiro Y]]
-
[[Category: Moco biosynthesis]]
+
[[Category: Wang B-C]]
-
[[Category: Molybdenum cofactor biosynthesis]]
+
[[Category: Yokoyama S]]
-
[[Category: National project on protein structural and functional analyse]]
+
-
[[Category: Nppsfa]]
+
-
[[Category: Riken structural genomics/proteomics initiative]]
+
-
[[Category: Rsgi]]
+
-
[[Category: Structural genomic]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 30 13:46:46 2010''
+

Current revision

Crystal structure of the molybdenum cofactor biosynthesis protein C (TTHA1789) from Thermus Theromophilus HB8 (H32 FORM)

PDB ID 3jqk

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3jqk"
Personal tools