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2c5h

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[[Image:2c5h.gif|left|200px]]<br /><applet load="2c5h" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2c5h, resolution 2.70&Aring;" />
 
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'''X-RAY CRYSTAL STRUCTURE OF 5'-FLUORODEOXYADENOSINE SYNTHASE FROM STREPTOMYCES CATTLEYA COMPLEXED WITH 2'DEOXY-ADENOSINE'''<br />
 
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==About this Structure==
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==X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from Streptomyces cattleya complexed with 2'deoxy-adenosine==
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2C5H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_cattleya Streptomyces cattleya] with CL, MET and 3D1 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Adenosyl-fluoride_synthase Adenosyl-fluoride synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.63 2.5.1.63] Known structural/functional Site: <scene name='pdbsite=AC1:MET Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C5H OCA].
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<StructureSection load='2c5h' size='340' side='right'caption='[[2c5h]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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[[Category: Adenosyl-fluoride synthase]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[2c5h]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_cattleya Streptomyces cattleya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C5H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C5H FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3D1:(2R,3S,5R)-5-(6-AMINO-9H-PURIN-9-YL)-TETRAHYDRO-2-(HYDROXYMETHYL)FURAN-3-OL'>3D1</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c5h OCA], [https://pdbe.org/2c5h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c5h RCSB], [https://www.ebi.ac.uk/pdbsum/2c5h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c5h ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FLA_STRCT FLA_STRCT] Involved in the biosynthesis of fluorometabolites. Catalyzes the formation of a C-F bond by combining S-adenosyl-L-methionine (SAM) and fluoride to generate 5'-fluoro-5'-deoxyadenosine (5'-FDA) and L-methionine. It can also use 2'-deoxyadenosine in place of adenosine as substrate.<ref>PMID:12860396</ref> <ref>PMID:14765200</ref> <ref>PMID:16370017</ref> <ref>PMID:16604208</ref> <ref>PMID:16720268</ref> <ref>PMID:17985882</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c5/2c5h_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c5h ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Streptomyces cattleya]]
[[Category: Streptomyces cattleya]]
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[[Category: Deng, H.]]
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[[Category: Deng H]]
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[[Category: Hagan, D.O.]]
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[[Category: McEwan AR]]
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[[Category: Mcewan, A.R.]]
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[[Category: McGlinchey RP]]
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[[Category: Mcglinchey, R.P.]]
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[[Category: Naismith JH]]
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[[Category: Naismith, J.H.]]
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[[Category: O'Hagan D]]
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[[Category: Robinson, D.R.]]
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[[Category: Robinson DR]]
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[[Category: Spencer, J.]]
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[[Category: Spencer J]]
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[[Category: 3D1]]
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[[Category: CL]]
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[[Category: MET]]
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[[Category: 5'-fluorodeoxyadenosine synthase]]
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[[Category: aza]]
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[[Category: fla]]
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[[Category: fluorinase]]
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[[Category: inhibitor]]
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[[Category: sam analogue]]
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[[Category: streptomyces cattleya]]
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[[Category: transferase]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 19:10:40 2007''
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Current revision

X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from Streptomyces cattleya complexed with 2'deoxy-adenosine

PDB ID 2c5h

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