3mva
From Proteopedia
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| - | {{Seed}} | ||
| - | [[Image:3mva.jpg|left|200px]] | ||
| - | + | ==Crystal structure of human MTERF1 bound to the termination sequence== | |
| - | + | <StructureSection load='3mva' size='340' side='right'caption='[[3mva]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3mva]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MVA FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mva OCA], [https://pdbe.org/3mva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mva RCSB], [https://www.ebi.ac.uk/pdbsum/3mva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mva ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/MTEF1_HUMAN MTEF1_HUMAN] Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand.<ref>PMID:20550934</ref> | |
| - | + | == Evolutionary Conservation == | |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | < | + | Check<jmol> |
| - | + | <jmolCheckbox> | |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mv/3mva_consurf.spt"</scriptWhenChecked> | |
| - | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |
| - | + | <text>to colour the structure by Evolutionary Conservation</text> | |
| - | + | </jmolCheckbox> | |
| - | == | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mva ConSurf]. |
| - | + | <div style="clear:both"></div> | |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Byrnes | + | [[Category: Large Structures]] |
| - | [[Category: Garcia-Diaz | + | [[Category: Byrnes J]] |
| - | [[Category: Hambardjieva | + | [[Category: Garcia-Diaz M]] |
| - | [[Category: Mejia | + | [[Category: Hambardjieva E]] |
| - | [[Category: Yakubovskaya | + | [[Category: Mejia E]] |
| - | + | [[Category: Yakubovskaya E]] | |
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Current revision
Crystal structure of human MTERF1 bound to the termination sequence
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