2xgj

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{{Seed}}
 
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[[Image:2xgj.png|left|200px]]
 
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==Structure of Mtr4, a DExH helicase involved in nuclear RNA processing and surveillance==
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The line below this paragraph, containing "STRUCTURE_2xgj", creates the "Structure Box" on the page.
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<StructureSection load='2xgj' size='340' side='right'caption='[[2xgj]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2xgj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XGJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XGJ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
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{{STRUCTURE_2xgj| PDB=2xgj | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xgj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xgj OCA], [https://pdbe.org/2xgj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xgj RCSB], [https://www.ebi.ac.uk/pdbsum/2xgj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xgj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MTR4_YEAST MTR4_YEAST] ATP-dependent RNA helicase required for the 3'-end formation of 5.8S RNA. Cofactor for the exosome complex that unwinds secondary structure in pre-rRNA. Required for nucleocytoplasmic transport of mRNA. May serve as a chaperone which translocates or normalizes the structure of mRNAs in preparation for export. Component of the TRAMP complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates.<ref>PMID:15828860</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xg/2xgj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xgj ConSurf].
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<div style="clear:both"></div>
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===STRUCTURE OF MTR4, A DEXH HELICASE INVOLVED IN NUCLEAR RNA PROCESSING AND SURVEILLANCE===
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==See Also==
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*[[Helicase 3D structures|Helicase 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 20566885 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_20566885}}
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==About this Structure==
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2XGJ is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XGJ OCA].
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==Reference==
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<ref group="xtra">PMID:20566885</ref><references group="xtra"/>
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[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Bonneau, F.]]
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[[Category: Bonneau F]]
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[[Category: Conti, E.]]
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[[Category: Conti E]]
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[[Category: Hentschel, J.]]
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[[Category: Hentschel J]]
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[[Category: Weir, J R.]]
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[[Category: Weir JR]]
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[[Category: Dead]]
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[[Category: Exosome]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-rna complex]]
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[[Category: Nucleotide-binding]]
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[[Category: Tramp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 7 08:05:21 2010''
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Current revision

Structure of Mtr4, a DExH helicase involved in nuclear RNA processing and surveillance

PDB ID 2xgj

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