2kzy
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2kzy is ON HOLD Authors: Garner, T.P., Long, J.E., Searle, M.S., Layfield, R. Description: Solution NMR structure of the ZNF216 A20 zinc finger ''...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution NMR structure of the ZNF216 A20 zinc finger== | |
| - | + | <StructureSection load='2kzy' size='340' side='right'caption='[[2kzy]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2kzy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KZY FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | '' | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzy OCA], [https://pdbe.org/2kzy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kzy RCSB], [https://www.ebi.ac.uk/pdbsum/2kzy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kzy ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ZFAN5_RAT ZFAN5_RAT] Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Rattus norvegicus]] | ||
| + | [[Category: Garner TP]] | ||
| + | [[Category: Layfield R]] | ||
| + | [[Category: Long JE]] | ||
| + | [[Category: Searle MS]] | ||
Current revision
Solution NMR structure of the ZNF216 A20 zinc finger
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