2rqu

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{{Seed}}
 
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[[Image:2rqu.jpg|left|200px]]
 
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==Solution structure of the complex between the DDEF1 SH3 domain and the APC SAMP1 motif==
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The line below this paragraph, containing "STRUCTURE_2rqu", creates the "Structure Box" on the page.
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<StructureSection load='2rqu' size='340' side='right'caption='[[2rqu]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2rqu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RQU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rqu OCA], [https://pdbe.org/2rqu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rqu RCSB], [https://www.ebi.ac.uk/pdbsum/2rqu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rqu ProSAT]</span></td></tr>
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{{STRUCTURE_2rqu| PDB=2rqu | SCENE= }}
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</table>
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== Function ==
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===Solution structure of the complex between the DDEF1 SH3 domain and the APC SAMP1 motif===
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[https://www.uniprot.org/uniprot/ASAP1_HUMAN ASAP1_HUMAN] Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity). Plays a role in ciliogenesis.<ref>PMID:20393563</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_20509626}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 20509626 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rq/2rqu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_20509626}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rqu ConSurf].
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2RQU is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQU OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:20509626</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ikegami, T.]]
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[[Category: Large Structures]]
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[[Category: Kaieda, S.]]
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[[Category: Ikegami T]]
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[[Category: Matsui, C.]]
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[[Category: Kaieda S]]
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[[Category: Mimori-Kiyosue, Y.]]
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[[Category: Matsui C]]
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[[Category: Cell junction]]
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[[Category: Mimori-Kiyosue Y]]
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[[Category: Disease mutation]]
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[[Category: Gap]]
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[[Category: Phosphoprotein]]
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[[Category: Samp motif]]
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[[Category: Sh3 domain]]
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[[Category: Signaling protein]]
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[[Category: Tumor suppressor]]
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[[Category: Wnt signaling pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 7 08:38:14 2010''
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Current revision

Solution structure of the complex between the DDEF1 SH3 domain and the APC SAMP1 motif

PDB ID 2rqu

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OCA

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