2xiv

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{{Seed}}
 
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[[Image:2xiv.jpg|left|200px]]
 
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==Structure of Rv1477, hypothetical invasion protein of Mycobacterium tuberculosis==
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The line below this paragraph, containing "STRUCTURE_2xiv", creates the "Structure Box" on the page.
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<StructureSection load='2xiv' size='340' side='right'caption='[[2xiv]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2xiv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XIV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XIV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_2xiv| PDB=2xiv | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xiv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xiv OCA], [https://pdbe.org/2xiv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xiv RCSB], [https://www.ebi.ac.uk/pdbsum/2xiv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xiv ProSAT]</span></td></tr>
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</table>
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===STRUCTURE OF RV1477, HYPOTHETICAL INVASION PROTEIN OF MYCOBACTERIUM TUBERCULOSIS===
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== Function ==
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[https://www.uniprot.org/uniprot/RIPA_MYCTU RIPA_MYCTU] Peptidoglycan endopeptidase that cleaves the bond between D-glutamate and meso-diaminopimelate. Binds and degrades high-molecular weight peptidoglycan from a number of Actinobacteria; activity is increased in the presence of RpfB and inhibited by PBP1A (ponA1). Required for normal separation of daughter cells after cell division and for cell wall integrity. Required for host cell invasion and intracellular survival in host macrophages.<ref>PMID:16495549</ref> <ref>PMID:17919286</ref> <ref>PMID:18463693</ref> <ref>PMID:20826344</ref> <ref>PMID:21864539</ref>
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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2XIV is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XIV OCA].
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Check<jmol>
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[[Category: Mycobacterium tuberculosis]]
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<jmolCheckbox>
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[[Category: Pogenberg, V.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xi/2xiv_consurf.spt"</scriptWhenChecked>
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[[Category: Tizzano, B.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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[[Category: Wilmanns, M.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Cell wall]]
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</jmolCheckbox>
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[[Category: Chap domain]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xiv ConSurf].
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[[Category: Nlpc/p60 domain]]
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<div style="clear:both"></div>
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[[Category: Resuscitation]]
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== References ==
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[[Category: Structural protein]]
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<references/>
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__TOC__
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 14 16:17:27 2010''
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Pogenberg V]]
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[[Category: Tizzano B]]
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[[Category: Wilmanns M]]

Current revision

Structure of Rv1477, hypothetical invasion protein of Mycobacterium tuberculosis

PDB ID 2xiv

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