3mce

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{{Seed}}
 
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[[Image:3mce.jpg|left|200px]]
 
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==Crystal structure of the NAC domain of alpha subunit of nascent polypeptide-associated complex(NAC)==
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The line below this paragraph, containing "STRUCTURE_3mce", creates the "Structure Box" on the page.
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<StructureSection load='3mce' size='340' side='right'caption='[[3mce]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3mce]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MCE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MCE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.396&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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{{STRUCTURE_3mce| PDB=3mce | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mce OCA], [https://pdbe.org/3mce PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mce RCSB], [https://www.ebi.ac.uk/pdbsum/3mce PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mce ProSAT]</span></td></tr>
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</table>
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===Crystal structure of the NAC domain of alpha subunit of nascent polypeptide-associated complex(NAC)===
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== Function ==
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[https://www.uniprot.org/uniprot/NACA_HUMAN NACA_HUMAN] Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters.<ref>PMID:9877153</ref> <ref>PMID:10982809</ref> <ref>PMID:15784678</ref>
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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3MCE is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MCE OCA].
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mc/3mce_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mce ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Li, X M.]]
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[[Category: Large Structures]]
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[[Category: Rao, Z.]]
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[[Category: Li XM]]
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[[Category: Wang, L.]]
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[[Category: Rao Z]]
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[[Category: Wang, L F.]]
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[[Category: Wang L]]
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[[Category: Zhang, W C.]]
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[[Category: Wang LF]]
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[[Category: Zhang, X J.C.]]
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[[Category: Zhang WC]]
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[[Category: Beta-barrel like structure]]
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[[Category: Zhang XJC]]
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[[Category: Chaperone]]
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[[Category: Homodimer]]
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[[Category: Nac]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 14 16:20:49 2010''
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Current revision

Crystal structure of the NAC domain of alpha subunit of nascent polypeptide-associated complex(NAC)

PDB ID 3mce

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