3ml4

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[[Image:3ml4.jpg|left|200px]]
 
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==Crystal structure of a complex between Dok7 PH-PTB and the MuSK juxtamembrane region==
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The line below this paragraph, containing "STRUCTURE_3ml4", creates the "Structure Box" on the page.
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<StructureSection load='3ml4' size='340' side='right'caption='[[3ml4]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ml4]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ML4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ML4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
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{{STRUCTURE_3ml4| PDB=3ml4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ml4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ml4 OCA], [https://pdbe.org/3ml4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ml4 RCSB], [https://www.ebi.ac.uk/pdbsum/3ml4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ml4 ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ml/3ml4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ml4 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Formation of the vertebrate neuromuscular junction requires, among others proteins, Agrin, a neuronally derived ligand, and the following muscle proteins: LRP4, the receptor for Agrin; MuSK, a receptor tyrosine kinase (RTK); and Dok7 (or Dok-7), a cytoplasmic adaptor protein. Dok7 comprises a pleckstrin-homology (PH) domain, a phosphotyrosine-binding (PTB) domain, and C-terminal sites of tyrosine phosphorylation. Unique among adaptor proteins recruited to RTKs, Dok7 is not only a substrate of MuSK, but also an activator of MuSK's kinase activity. Here, we present the crystal structure of the Dok7 PH-PTB domains in complex with a phosphopeptide representing the Dok7-binding site on MuSK. The structure and biochemical data reveal a dimeric arrangement of Dok7 PH-PTB that facilitates trans-autophosphorylation of the kinase activation loop. The structure provides the molecular basis for MuSK activation by Dok7 and for rationalizing several Dok7 loss-of-function mutations found in patients with congenital myasthenic syndromes.
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===Crystal structure of a complex between Dok7 PH-PTB and the MuSK juxtamembrane region===
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The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization.,Bergamin E, Hallock PT, Burden SJ, Hubbard SR Mol Cell. 2010 Jul 9;39(1):100-9. PMID:20603078<ref>PMID:20603078</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_20603078}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3ml4" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 20603078 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20603078}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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3ML4 is a 8 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ML4 OCA].
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==Reference==
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<ref group="xtra">PMID:20603078</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Bergamin, E.]]
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[[Category: Bergamin E]]
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[[Category: Hubbard, S R.]]
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[[Category: Hubbard SR]]
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[[Category: Adapter protein]]
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[[Category: Dimerization]]
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[[Category: Signaling protein]]
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[[Category: Tyrosine phosphorylation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 14 16:21:06 2010''
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Current revision

Crystal structure of a complex between Dok7 PH-PTB and the MuSK juxtamembrane region

PDB ID 3ml4

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