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3n1e

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{{Seed}}
 
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[[Image:3n1e.jpg|left|200px]]
 
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==Vps54 C-terminal domain==
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The line below this paragraph, containing "STRUCTURE_3n1e", creates the "Structure Box" on the page.
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<StructureSection load='3n1e' size='340' side='right'caption='[[3n1e]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3n1e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N1E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N1E FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.702&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_3n1e| PDB=3n1e | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n1e OCA], [https://pdbe.org/3n1e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n1e RCSB], [https://www.ebi.ac.uk/pdbsum/3n1e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n1e ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/VPS54_MOUSE VPS54_MOUSE] Note=Defects in Vps54 are the cause of wobbler phenotype (wr). Wr is autosomal recessive and is a spontaneous mutation discovered almost 50 years ago. It causes spinal muscular atrophy and defective spermiogenesis.<ref>PMID:16244655</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/VPS54_MOUSE VPS54_MOUSE] May be involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n1/3n1e_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n1e ConSurf].
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<div style="clear:both"></div>
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===Vps54 C-terminal domain===
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==See Also==
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*[[Vacuolar protein sorting-associated protein 3D structures|Vacuolar protein sorting-associated protein 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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3N1E is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N1E OCA].
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Abascal-Palacios, G.]]
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[[Category: Abascal-Palacios G]]
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[[Category: Bonifacino, J S.]]
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[[Category: Bonifacino JS]]
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[[Category: Hierro, A.]]
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[[Category: Hierro A]]
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[[Category: Kajava, A.]]
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[[Category: Kajava A]]
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[[Category: Perez-Victoria, F J.]]
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[[Category: Perez-Victoria FJ]]
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[[Category: Pioro, E P.]]
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[[Category: Pioro EP]]
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[[Category: Tascon, I.]]
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[[Category: Tascon I]]
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[[Category: Garp.]]
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[[Category: Golgi apparatus]]
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[[Category: Spinal muscular atrophy]]
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[[Category: Tethering complex]]
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[[Category: Transport protein]]
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[[Category: Vesicle trafficking]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 14 16:22:39 2010''
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Current revision

Vps54 C-terminal domain

PDB ID 3n1e

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