3h7h

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{{Seed}}
 
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[[Image:3h7h.png|left|200px]]
 
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==Crystal structure of the human transcription elongation factor DSIF, hSpt4/hSpt5 (176-273)==
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The line below this paragraph, containing "STRUCTURE_3h7h", creates the "Structure Box" on the page.
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<StructureSection load='3h7h' size='340' side='right'caption='[[3h7h]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3h7h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H7H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H7H FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3h7h| PDB=3h7h | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h7h OCA], [https://pdbe.org/3h7h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h7h RCSB], [https://www.ebi.ac.uk/pdbsum/3h7h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h7h ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPT4H_HUMAN SPT4H_HUMAN] component of the drb sensitivity-inducing factor complex (dsif complex), which regulates mrna processing and transcription elongation by rna polymerase ii dsif positively regulates mrna capping by stimulating the mrna guanylyltransferase activity of rngtt/cap1a dsif also acts cooperatively with the negative elongation factor complex (nelf complex) to enhance transcriptional pausing at sites proximal to the promoter transcriptional pausing may facilitate the assembly of an elongation competent rna polymerase ii complex dsif and nelf promote pausing by inhibition of the transcription elongation factor tfiis/s-ii tfiis/s-ii binds to rna polymerase ii at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme cleavage of blocked transcripts by rna polymerase ii promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites dsif can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the hiv- 1 nuclear transcriptional activator, tat dsif acts to suppress transcriptional pausing in transcripts derived from the hiv-1 ltr and blocks premature release of hiv-1 transcripts at terminator sequences
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h7/3h7h_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h7h ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of the human transcription elongation factor DSIF, hSpt4/hSpt5 (176-273)===
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==See Also==
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*[[Elongation factor 3D structures|Elongation factor 3D structures]]
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 19860741 is the PubMed ID number.
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{{ABSTRACT_PUBMED_19860741}}
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==About this Structure==
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3H7H is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H7H OCA].
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==Reference==
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<ref group="xtra">PMID:19860741</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Martins, B M.]]
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[[Category: Large Structures]]
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[[Category: Rosch, P.]]
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[[Category: Martins BM]]
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[[Category: Wenzel, S.]]
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[[Category: Rosch P]]
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[[Category: Wohrl, B M.]]
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[[Category: Wenzel S]]
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[[Category: Activator]]
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[[Category: Wohrl BM]]
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[[Category: Helices surrounding beta sheet]]
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[[Category: Metal-binding]]
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[[Category: Methylation]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Repressor]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 21 09:52:36 2010''
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Current revision

Crystal structure of the human transcription elongation factor DSIF, hSpt4/hSpt5 (176-273)

PDB ID 3h7h

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