2kv6

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[[Image:2kv6.jpg|left|200px]]
 
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==Tetrapeptide KWKK conjugated to oligonucleotide duplex by a trimethylene tether==
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The line below this paragraph, containing "STRUCTURE_2kv6", creates the "Structure Box" on the page.
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<StructureSection load='2kv6' size='340' side='right'caption='[[2kv6]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2kv6]] is a 3 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KV6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KV6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 1 model</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0AD:2-DEOXY-N-PROPYLGUANOSINE+5-(DIHYDROGEN+PHOSPHATE)'>0AD</scene></td></tr>
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{{STRUCTURE_2kv6| PDB=2kv6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kv6 OCA], [https://pdbe.org/2kv6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kv6 RCSB], [https://www.ebi.ac.uk/pdbsum/2kv6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kv6 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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DNA-protein conjugates are potentially repaired via proteolytic digestion to DNA-peptide conjugates. The latter have been modeled with the amino-terminal lysine of the peptide KWKK conjugated via a trimethylene linkage to the N(2)-dG amine positioned in 5'-d(GCTAGCXAGTCC)-3'.5'-d(GGACTCGCTAGC)-3' (X = N(2)-dG-trimethylene link-KWKK). This linkage is a surrogate for the reversible linkage formed by the gamma-OH-1,N(2)-propanodeoxyguanosine (gamma-OH-PdG) adduct. This conjugated KWKK stabilizes the DNA. Amino acids K(26), W(27), K(28), and K(29) are in the minor groove. The W(27) indolyl group does not intercalate into the DNA. The G(7) N(2) amine and the K(26) N-terminal amine nitrogens are in the trans configuration with respect to the C(alpha) or C(gamma) of the trimethylene tether, respectively. The structure of this DNA-KWKK conjugate is discussed in the context of its biological processing.
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===Tetrapeptide KWKK conjugated to oligonucleotide duplex by a trimethylene tether===
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Minor Groove Orientation of the KWKK Peptide Tethered via the N-Terminal Amine to the Acrolein-Derived 1,N(2)-gamma-Hydroxypropanodeoxyguanosine Lesion with a Trimethylene Linkage .,Huang H, Kozekov ID, Kozekova A, Rizzo CJ, McCullough AK, Lloyd RS, Stone MP Biochemistry. 2010 Jul 6. PMID:20604523<ref>PMID:20604523</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2kv6" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 20604523 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_20604523}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2KV6 is a 3 chains structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KV6 OCA].
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[[Category: Huang H]]
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[[Category: Kozekov ID]]
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==Reference==
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[[Category: Kozekova A]]
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<ref group="xtra">PMID:20604523</ref><references group="xtra"/>
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[[Category: LLoyd RS]]
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[[Category: Huang, H.]]
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[[Category: McCullough A]]
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[[Category: Kozekov, I D.]]
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[[Category: Rizzo CJ]]
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[[Category: Kozekova, A.]]
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[[Category: Stone MP]]
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[[Category: LLoyd, R S.]]
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[[Category: McCullough, A.]]
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[[Category: Rizzo, C J.]]
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[[Category: Stone, M P.]]
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[[Category: Acrolein-dg adduct]]
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[[Category: Dna binding protein-dna complex]]
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[[Category: Dna-peptide complex]]
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[[Category: Dna-peptide conjugate]]
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[[Category: Trimethylene]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 21 10:12:37 2010''
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Current revision

Tetrapeptide KWKK conjugated to oligonucleotide duplex by a trimethylene tether

PDB ID 2kv6

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